Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C30H24N2O13.2Na |
| Molecular Weight | 666.4967 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].OC(=O)CN(CC(O)=O)CC1=C(O)C=C2OC3=CC(O)=C(CN(CC([O-])=O)CC([O-])=O)C=C3C4(OC(=O)C5=CC=CC=C45)C2=C1
InChI
InChIKey=ZPDXOJYVKULICC-UHFFFAOYSA-L
InChI=1S/C30H26N2O13.2Na/c33-21-7-23-19(5-15(21)9-31(11-25(35)36)12-26(37)38)30(18-4-2-1-3-17(18)29(43)45-30)20-6-16(22(34)8-24(20)44-23)10-32(13-27(39)40)14-28(41)42;;/h1-8,33-34H,9-14H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42);;/q;2*+1/p-2
Oftasceine is a fluorescent dye or luminescent agent. It was recommended for the use as an effective agent for the blood-retinal barrier integrity studies. It was used to detect drug interactions with multidrug resistance proteins because it is an effective substrate of the multidrug resistance transporter 1P-glycoprotein and the multidrug resistance-related protein. The Oftasceine assay can be used as a quantitative, standardized, inexpensive screening test in a routine clinical laboratory setting. The assay detects both P-glycoprotein and multidrug resistance-associated protein activities, and identifies acute myeloid leukaemia patients with unfavorable therapy responses. It is used in ophthalmic solutions as a staining agent when fitting hydrogel contact lens. The use of a fluorexon dye-impregnated strip (pre-wetted with preservative-free saline) yielded comparable results with a fluorescein strip for assessments of tear film stability based on tear film break-up time.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1. | 2002-05-06 |
|
| Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. | 2002-05 |
|
| Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. | 2002-05 |
|
| Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells. | 2002-05 |
|
| Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations. | 2002-04-23 |
|
| Mitochondria are morphologically and functionally heterogeneous within cells. | 2002-04-02 |
|
| Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice. | 2002-04 |
|
| An improved labelling technique for monitoring microcrack growth in compact bone. | 2002-04 |
|
| Cholesterol modulates interaction between an amphipathic class A peptide, Ac-18A-NH2, and phosphatidylcholine bilayers. | 2002-03-26 |
|
| Characterization of flavonoid--biomembrane interactions. | 2002-03-01 |
|
| Ectopic mineralization of articular cartilage in the bullfrog Rana catesbeiana and its possible involvement in bone closure. | 2002-03 |
|
| Binding of ricin A-chain to negatively charged phospholipid vesicles leads to protein structural changes and destabilizes the lipid bilayer. | 2002-02-26 |
|
| Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma. | 2002-02-15 |
|
| Coupling fiber optics to a permeation liquid membrane for heavy metal sensor development. | 2002-02-01 |
|
| Canine prostate induces new bone formation in mouse calvaria: A model of osteoinduction by prostate tissue. | 2002-02-01 |
|
| Evaluation of mitochondrial function and membrane integrity by dual fluorescent staining for assessment of sperm status in rats. | 2002-02 |
|
| Influence of nicotine administration on different implant surfaces: a histometric study in rabbits. | 2002-02 |
|
| Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells. | 2002-02 |
|
| Effects of immobilization followed by remobilization on mineral density, histomorphometric features, and formation of the bones of the metacarpophalangeal joint in horses. | 2002-02 |
|
| Tendon healing in a bone tunnel. Part II: Histologic analysis after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep. | 2002-02 |
|
| In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. | 2002-02 |
|
| Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells. | 2002-02 |
|
| Evaluation of the clinical relevance of the expression and function of P-glycoprotein, multidrug resistance protein and lung resistance protein in patients with primary acute myelogenous leukemia. | 2002-02 |
|
| Reconsideration of drug release from temperature-sensitive liposomes. | 2002-01 |
|
| Effect of eyelid closure and overnight contact lens wear on viability of surface epithelial cells in rabbit cornea. | 2002-01 |
|
| Isoflurane prevents delayed cell death in an organotypic slice culture model of cerebral ischemia. | 2002-01 |
|
| High throughput fluorescence assays for the measurement of mitochondrial activity in intact human neuroblastoma cells. | 2001-12 |
|
| Interaction of SMKT, a killer toxin produced by Pichia farinosa, with the yeast cell membranes. | 2001-12 |
|
| Effects of clotrimazole on transport mediated by multidrug resistance associated protein 1 (MRP1) in human erythrocytes and tumour cells. | 2001-12 |
|
| Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells. | 2001-11-02 |
|
| Characteristics of newly formed bone during guided bone regeneration: observations by immunohistochemistry and confocal laser scanning microscopy. | 2001-11 |
|
| Down-regulation of cell adhesion molecules LFA-1 and ICAM-1 after in vitro treatment with the anti-TNF-alpha agent thalidomide. | 2001-11 |
|
| Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons. | 2001-11 |
|
| Extrusion of fluorescein diacetate by multidrug-resistant Candida albicans. | 2001-11 |
|
| Intracellular drug delivery using low-frequency ultrasound: quantification of molecular uptake and cell viability. | 2001-11 |
|
| Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology. | 2001-11 |
|
| Calcein-acetyoxymethyl cytotoxicity assay: standardization of a method allowing additional analyses on recovered effector cells and supernatants. | 2001-11 |
|
| Effects of the acyl chain composition of phosphatidylcholines on the stability of freeze-dried small liposomes in the presence of maltose. | 2001-11 |
|
| Intracellular delivery mediated by an ethosomal carrier. | 2001-11 |
|
| Visualizing normal and defective bone development in zebrafish embryos using the fluorescent chromophore calcein. | 2001-10-15 |
|
| Investigation of the cellular uptake of E-Selectin-targeted immunoliposomes by activated human endothelial cells. | 2001-10-01 |
|
| Localization of zinc after in vitro mineralization in osteoblastic cells. | 2001-10 |
|
| Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies. | 2001-10 |
|
| Mechanism of clofibrate hepatotoxicity: mitochondrial damage and oxidative stress in hepatocytes. | 2001-09-01 |
|
| The extent of matrix damage and chondrocyte death in mechanically traumatized articular cartilage explants depends on rate of loading. | 2001-09 |
|
| Cell mediated cytotoxicity assessment by relative changes in viable target absolute counts. | 2001-08 |
|
| Glycine blocks opening of a death channel in cultured hepatic sinusoidal endothelial cells during chemical hypoxia. | 2001-08 |
|
| Sonoluminescence as an indicator of cell membrane disruption by acoustic cavitation. | 2001-06 |
|
| Masticatory muscle function and transverse dentofacial growth. | 2001 |
|
| The effect of micromovement on callus formation. | 2001 |
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W252XL2SR8
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13456549
Created by
admin on Wed Apr 02 12:08:38 GMT 2025 , Edited by admin on Wed Apr 02 12:08:38 GMT 2025
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1945975-98-3
Created by
admin on Wed Apr 02 12:08:38 GMT 2025 , Edited by admin on Wed Apr 02 12:08:38 GMT 2025
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
