Details
Stereochemistry | ACHIRAL |
Molecular Formula | C18H19F2NO5 |
Molecular Weight | 367.344 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)C1=C(C)NC(C)=C(C1C2=C(OC(F)F)C=CC=C2)C(=O)OC
InChI
InChIKey=AZVFIZVKGSPGPK-UHFFFAOYSA-N
InChI=1S/C18H19F2NO5/c1-9-13(16(22)24-3)15(14(10(2)21-9)17(23)25-4)11-7-5-6-8-12(11)26-18(19)20/h5-8,15,18,21H,1-4H3
Riodipine is the blocker of calcium channels of L-type. Riodipine is indicated for the treatment of arterial hypertension, prevention of attacks of angina pectoris. Antiepileptic effect of riodipine was manifested by a decreased frequency and amplitude of interictal discharges and a less frequent appearance of ictal discharges. Riodipine increased latency to first convulsive episodes and delayed the development of generalized tonic-clonic seizures. Detected side effects are: arterial hypotension, tachycardia, hypostasis of shins, increase of a daily urine. Allergic reactions to the drug are possible. Nitrates, tricyclic antidepressants, and other anti-hypertensive drugs are able to potentiate of riodipine effects.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2111408 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2165822 |
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Target ID: CHEMBL2095229 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Foridon Approved UseIndicated for the treatment of arterial hypertension the I-II foot, hypertensive crisis, prevention of attacks of stenocardia against the increased arterial pressure, prevention of attacks of an angina of exertion. Launch Date1987 |
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Primary | Foridon Approved UseIndicated for the treatment of arterial hypertension the I-II foot, hypertensive crisis, prevention of attacks of stenocardia against the increased arterial pressure, prevention of attacks of an angina of exertion. Launch Date1987 |
Sample Use Guides
In Vivo Use Guide
Sources: http://infomeds.net/foridon.html
20-30 mg 3 times a day. The maximum daily dose - 150 mg. Course of treatment 2-3 weeks
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2992533
Riodipine (10(-8) mol/l--10(-6) mol/l) suppresses contraction force and diminishes frequency of spontaneous contractions of the rabbit atria, and also displays antagonism to the effect of Ca2+ upon rabbit auricle contractions.
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NCI_THESAURUS |
C333
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C76582
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Riodipine
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C045912
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ACTIVE MOIETY