U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C24H20F2N4
Molecular Weight 402.4392
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GSK-1521498

SMILES

FC1=CC(=CC(F)=C1CNC2CC3=C(C2)C=CC=C3)C4=CC=CC(=C4)C5=NNC=N5

InChI

InChIKey=WIEDUMBCZQRGSY-UHFFFAOYSA-N
InChI=1S/C24H20F2N4/c25-22-11-19(15-6-3-7-18(8-15)24-28-14-29-30-24)12-23(26)21(22)13-27-20-9-16-4-1-2-5-17(16)10-20/h1-8,11-12,14,20,27H,9-10,13H2,(H,28,29,30)

HIDE SMILES / InChI
GSK-1521498 is being tested for treatment of over-eating behaviors and other control-related eating problems. This compound inhibits the effects of opioids, which are known to be involved in controlling how much we eat and the pleasure associated with eating. GSK-1521498 has also been evaluated for treatment of alcoholism, potentially promoting abstinence and preventing relapse in alcohol addiction.

Approval Year

Name Type Language
GSK-1521498
Code English
GSK1521498
Preferred Name English
GSK1521498H
Code English
N-((3,5-DIFLUORO-3'-(1H-1,2,4-TRIAZOL-3-YL)-4-BIPHENYLYL)METHYL(-2,3-DIHYDRO-1H-INDEN-2-AMINE
Common Name English
Code System Code Type Description
PUBCHEM
24737629
Created by admin on Mon Mar 31 21:21:15 GMT 2025 , Edited by admin on Mon Mar 31 21:21:15 GMT 2025
PRIMARY
EPA CompTox
DTXSID40143501
Created by admin on Mon Mar 31 21:21:15 GMT 2025 , Edited by admin on Mon Mar 31 21:21:15 GMT 2025
PRIMARY
FDA UNII
W0UTB622GK
Created by admin on Mon Mar 31 21:21:15 GMT 2025 , Edited by admin on Mon Mar 31 21:21:15 GMT 2025
PRIMARY
CAS
1007573-18-3
Created by admin on Mon Mar 31 21:21:15 GMT 2025 , Edited by admin on Mon Mar 31 21:21:15 GMT 2025
PRIMARY
DRUG BANK
DB12886
Created by admin on Mon Mar 31 21:21:15 GMT 2025 , Edited by admin on Mon Mar 31 21:21:15 GMT 2025
PRIMARY