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Details

Stereochemistry RACEMIC
Molecular Formula C11H16ClN3O4S2
Molecular Weight 353.845
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BUTHIAZIDE

SMILES

CC(C)CC1NC2=CC(Cl)=C(C=C2S(=O)(=O)N1)S(N)(=O)=O

InChI

InChIKey=HGBFRHCDYZJRAO-UHFFFAOYSA-N
InChI=1S/C11H16ClN3O4S2/c1-6(2)3-11-14-8-4-7(12)9(20(13,16)17)5-10(8)21(18,19)15-11/h4-6,11,14-15H,3H2,1-2H3,(H2,13,16,17)

HIDE SMILES / InChI

Description

Buthiazide (or Butizide) is a diuretic of the thiazide class. It was used for the treatment of mild to moderate essential hypertension. Buthiazide reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

PubMed

Sample Use Guides

In Vivo Use Guide
The combination of 100 mg spironolactone either with 5 mg bendrofluazide or with 10 mg butizide increased significantly the diuresis over the whole day.
Route of Administration: Oral