Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H13ClN2O |
| Molecular Weight | 284.74 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@]1(N2CCN=C2C3=C1C=CC=C3)C4=CC=C(Cl)C=C4
InChI
InChIKey=ZPXSCAKFGYXMGA-MRXNPFEDSA-N
InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2/t16-/m1/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/24214825
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24214825
Mazindol was developed as an appetite suppressant. It exists in a dynamic equilibrium between three isomers (the keto and the R and S–ol forms, respectively) with the R or S–ol being the only relevant forms at physiologic pH. Both S- and R-mazindol supposed to target human serotonin and dopamine transporters. R-mazindol is the biologically relevant enantiomer.
CNS Activity
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/804553
Curator's Comment: Originator of R-enantiomer of mazindol is unknown. Mazindol was developed at Sandoz.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL228 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24214825 |
|||
Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24214825 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
VYJ123WTU1
Created by
admin on Mon Mar 31 23:07:07 GMT 2025 , Edited by admin on Mon Mar 31 23:07:07 GMT 2025
|
PRIMARY | |||
|
76961208
Created by
admin on Mon Mar 31 23:07:07 GMT 2025 , Edited by admin on Mon Mar 31 23:07:07 GMT 2025
|
PRIMARY | |||
|
1337994-14-5
Created by
admin on Mon Mar 31 23:07:07 GMT 2025 , Edited by admin on Mon Mar 31 23:07:07 GMT 2025
|
PRIMARY |
SUBSTANCE RECORD