EFEGATRAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H32N6O3
Molecular Weight	416.5172
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN[C@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C=O

InChI

InChIKey=KAGLWQUWUNBAOO-KSZLIROESA-N

InChI=1S/C21H32N6O3/c1-24-17(13-15-7-3-2-4-8-15)20(30)27-12-6-10-18(27)19(29)26-16(14-28)9-5-11-25-21(22)23/h2-4,7-8,14,16-18,24H,5-6,9-13H2,1H3,(H,26,29)(H4,22,23,25)/t16-,17+,18-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2342067 | https://www.ncbi.nlm.nih.gov/pubmed/1641823 | https://www.ncbi.nlm.nih.gov/pubmed/1641827 | https://www.ncbi.nlm.nih.gov/pubmed/16001314 | https://adisinsight.springer.com/drugs/800001951

Efegatran (GYKI 14766; LY 294468) is a tripeptide D-methyl-phenylalanyl-prolyl-arginal thrombin inhibitor. It was developed by IVAX for the potential treatment of thromboembolic disorders, mainly myocardial infarction. However, information about the further development is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H.	1990 Jun	2342067

Patents

Name

Type

Language

EFEGATRAN

Official Name

English

LY294468

Code

English

L-PROLINAMIDE, N-METHYL-D-PHENYLALANYL-N-(4-((AMINOIMINOMETHYL)AMINO)-1-FORMYLBUTYL)-, (S)-

Systematic Name

English

LY-294468

Code

English

efegatran [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C783