TEMPO

Investigational

CC1(C)CCCC(C)(C)N1[O]

InChIKey=VUZNLSBZRVZGIK-UHFFFAOYSA-N

InChI=1S/C9H19NO/c1-8(2)6-5-7-9(3,4)10(8)11/h11H,5-7H2,1-4H3

Targets

Primary Target	Pharmacology	Condition	Potency
reactive oxygen species biosynthetic process 37 Target ID: GO:1903409 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26577173	Inhibitor 8297

PubMed

Title	Date	PubMed
Reactive oxygen species regulate macrophage scavenger receptor type I, but not type II, in the human monocytic cell line THP-1.	1998 Jun	9614211
Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells.	2004 Jan	14675044
Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin.	2005 Oct 14	16024921
Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells.	2009 Apr	19162161
Molecular investigation of the effects of lindane in rat hepatocytes: microarray and mechanistic studies.	2011 Dec	22001173
The inhibitory effect of raloxifene on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells is mediated through a ROS/p38 MAPK/CREB pathway to the up-regulation of heme oxygenase-1 independent of estrogen receptor.	2011 Feb	20888885
Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells.	2015 Jun 25	25882087

Name

Type

Language

TEMPO

Common Name

English

2,2,6,6-TETRAMETHYL-1-PIPERIDINYLOXY

Common Name

English

TEMPO [MI]

Common Name

English

2,2,6,6-TETRAMETHYLPIPERIDINE-1-OXYL

Systematic Name

English

2,2,6,6-TETRAMETHYLPENTAMETHYLENE NITROXIDE

Common Name

English

1-PIPERIDINYLOXY,2,2,6,6-TETRAMETHYL-,

Common Name

English

4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINE-1-OXYL-

Systematic Name

English

4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINE-1-OXYL

Systematic Name

English

Code System Code Type Description

CHEBI

32849