Details
Stereochemistry | ACHIRAL |
Molecular Formula | C24H27FN2O4 |
Molecular Weight | 426.4806 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(=CC=C1OCCCN2CCC(CC2)C3=NOC4=CC(F)=CC=C34)C(C)=O
InChI
InChIKey=XMXHEBAFVSFQEX-UHFFFAOYSA-N
InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
DescriptionSources: http://www.drugbank.ca/drugs/DB04946Curator's Comment: Description was created based on several sources, including
http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/022192s015lbl.pdf
Sources: http://www.drugbank.ca/drugs/DB04946
Curator's Comment: Description was created based on several sources, including
http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/022192s015lbl.pdf
Iloperidone, also known as Fanapt, Fanapta, and previously known as Zomaril, is an atypical antipsychotic for the treatment of schizophrenia. Iloperidone shows high affinity and maximal receptor occupancy for dopamine D2 receptors in the caudate nucleus and putamen of the brains of schizophrenic patients. The improvement in cognition is attributed to iloperidone's high affinity for α adrenergic receptors. Iloperidone also binds with high affinity to serotonin 5-HT2a and dopamine 3 receptors. Iloperidone binds with moderate affinity to dopamine D4, serotonin 5-HT6 and 5-HT7, and norepinephrine NEα1 receptors. Furthermore, iloperidone binds with weak affinity to serotonin 5-HT1A, dopamine D1, and histamine H1 receptors. Iloperidone is indicated for the treatment of acute schizophrenia.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL217 Sources: http://www.drugbank.ca/drugs/DB04946 |
110.0 nM [IC50] | ||
Target ID: CHEMBL1907610 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7562515 |
0.4 nM [IC50] | ||
Target ID: CHEMBL273 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7562515 |
210.0 nM [IC50] | ||
Target ID: CHEMBL327 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7707315 |
0.4 nM [IC50] | ||
Target ID: CHEMBL240 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22465688 |
161.0 nM [IC50] | ||
Target ID: CHEMBL224 Sources: http://www.drugbank.ca/drugs/DB04946 |
0.011 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | FANAPT Approved UseFANAPT is an atypical antipsychotic indicated for the treatment of schizophrenia in adults. Launch Date2009 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
2.79 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21034370/ |
3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered: |
ILOPERIDONE plasma | Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
29.4 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21034370/ |
3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered: |
ILOPERIDONE plasma | Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
17.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21034370/ |
3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered: |
ILOPERIDONE plasma | Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
18 h |
3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered: |
ILOPERIDONE plasma | Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
5% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21034370/ |
3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered: |
ILOPERIDONE plasma | Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
3% |
3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered: |
ILOPERIDONE plasma | Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
32 mg 1 times / day multiple, oral MTD Dose: 32 mg, 1 times / day Route: oral Route: multiple Dose: 32 mg, 1 times / day Sources: |
unhealthy, 18 - 55 n = 24 Health Status: unhealthy Condition: Schizophrenia Age Group: 18 - 55 Population Size: 24 Sources: |
|
24 mg 1 times / day multiple, oral Highest studied dose Dose: 24 mg, 1 times / day Route: oral Route: multiple Dose: 24 mg, 1 times / day Sources: Page: p.3 |
unhealthy, 42 (13.1) n = 31 Health Status: unhealthy Condition: Bipolar Disorder Age Group: 42 (13.1) Sex: M+F Population Size: 31 Sources: Page: p.3 |
|
438 mg multiple, oral (total) Overdose Dose: 438 mg Route: oral Route: multiple Dose: 438 mg Sources: Page: p.17 |
unhealthy n = 1 Health Status: unhealthy Condition: Schizophrenia Population Size: 1 Sources: Page: p.17 |
Other AEs: Extrapyramidal symptoms, Electrocardiogram QTc interval prolonged... Other AEs: Extrapyramidal symptoms Sources: Page: p.17Electrocardiogram QTc interval prolonged |
576 mg single, oral Overdose Dose: 576 mg Route: oral Route: single Dose: 576 mg Sources: Page: p.17 |
unhealthy n = 1 Health Status: unhealthy Condition: Schizophrenia Population Size: 1 Sources: Page: p.17 |
|
10 mg 2 times / day multiple, oral Recommended Dose: 10 mg, 2 times / day Route: oral Route: multiple Dose: 10 mg, 2 times / day Sources: Page: p.9 |
unhealthy n = 874 Health Status: unhealthy Condition: Schizophrenia Population Size: 874 Sources: Page: p.9 |
Other AEs: Somnolence... Other AEs: Somnolence (11.9%) Sources: Page: p.9 |
12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.7 |
Other AEs: Orthostatic hypotension... Other AEs: Orthostatic hypotension (5%) Sources: Page: p.7 |
12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.7 |
Other AEs: Weight gain... Other AEs: Weight gain (18%) Sources: Page: p.7 |
12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.8 |
unhealthy n = 3210 Health Status: unhealthy Condition: Schizophrenia Population Size: 3210 Sources: Page: p.8 |
Other AEs: Gynecomastia, Galactorrhea... Other AEs: Gynecomastia (0.1%) Sources: Page: p.8Galactorrhea (0.2%) |
12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.8 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.8 |
Other AEs: Hyperprolactinemia... Other AEs: Hyperprolactinemia (26%) Sources: Page: p.8 |
12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy n = 1344 Health Status: unhealthy Condition: Schizophrenia Population Size: 1344 Sources: Page: p.7 |
Other AEs: Syncope... Other AEs: Syncope (0.4%) Sources: Page: p.7 |
12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy n = 1344 Health Status: unhealthy Condition: Schizophrenia Population Size: 1344 Sources: Page: p.7 |
Other AEs: Seizures... Other AEs: Seizures (0.1%) Sources: Page: p.7 |
12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.7 |
Other AEs: Leukopenia, Neutropenia... Other AEs: Leukopenia Sources: Page: p.7Neutropenia Agranulocytosis |
12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.8 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.8 |
Other AEs: Temperature regulation disorder, Dysphagia... Other AEs: Temperature regulation disorder Sources: Page: p.8Dysphagia |
12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.9 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.9 |
Other AEs: Suicide attempt, Priapism... Other AEs: Suicide attempt Sources: Page: p.9Priapism |
12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.4 |
unhealthy n = 160 Health Status: unhealthy Condition: Schizophrenia Population Size: 160 Sources: Page: p.4 |
Other AEs: QT interval prolonged... Other AEs: QT interval prolonged Sources: Page: p.4 |
12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.5 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.5 |
Other AEs: Neuroleptic malignant syndrome... Other AEs: Neuroleptic malignant syndrome Sources: Page: p.5 |
12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.6 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.6 |
Other AEs: Tardive dyskinesia, Hyperglycemia... Other AEs: Tardive dyskinesia Sources: Page: p.6Hyperglycemia |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Electrocardiogram QTc interval prolonged | 438 mg multiple, oral (total) Overdose Dose: 438 mg Route: oral Route: multiple Dose: 438 mg Sources: Page: p.17 |
unhealthy n = 1 Health Status: unhealthy Condition: Schizophrenia Population Size: 1 Sources: Page: p.17 |
|
Extrapyramidal symptoms | 438 mg multiple, oral (total) Overdose Dose: 438 mg Route: oral Route: multiple Dose: 438 mg Sources: Page: p.17 |
unhealthy n = 1 Health Status: unhealthy Condition: Schizophrenia Population Size: 1 Sources: Page: p.17 |
|
Somnolence | 11.9% | 10 mg 2 times / day multiple, oral Recommended Dose: 10 mg, 2 times / day Route: oral Route: multiple Dose: 10 mg, 2 times / day Sources: Page: p.9 |
unhealthy n = 874 Health Status: unhealthy Condition: Schizophrenia Population Size: 874 Sources: Page: p.9 |
Orthostatic hypotension | 5% | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.7 |
Weight gain | 18% | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.7 |
Gynecomastia | 0.1% | 12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.8 |
unhealthy n = 3210 Health Status: unhealthy Condition: Schizophrenia Population Size: 3210 Sources: Page: p.8 |
Galactorrhea | 0.2% | 12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.8 |
unhealthy n = 3210 Health Status: unhealthy Condition: Schizophrenia Population Size: 3210 Sources: Page: p.8 |
Hyperprolactinemia | 26% | 12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.8 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.8 |
Syncope | 0.4% | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy n = 1344 Health Status: unhealthy Condition: Schizophrenia Population Size: 1344 Sources: Page: p.7 |
Seizures | 0.1% | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy n = 1344 Health Status: unhealthy Condition: Schizophrenia Population Size: 1344 Sources: Page: p.7 |
Agranulocytosis | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.7 |
|
Leukopenia | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.7 |
|
Neutropenia | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.7 |
|
Dysphagia | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.8 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.8 |
|
Temperature regulation disorder | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.8 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.8 |
|
Priapism | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.9 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.9 |
|
Suicide attempt | 12 mg 2 times / day multiple, oral (max) Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.9 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.9 |
|
QT interval prolonged | 12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.4 |
unhealthy n = 160 Health Status: unhealthy Condition: Schizophrenia Population Size: 160 Sources: Page: p.4 |
|
Neuroleptic malignant syndrome | 12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.5 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.5 |
|
Hyperglycemia | 12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.6 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.6 |
|
Tardive dyskinesia | 12 mg 2 times / day multiple, oral Recommended Dose: 12 mg, 2 times / day Route: oral Route: multiple Dose: 12 mg, 2 times / day Sources: Page: p.6 |
unhealthy Health Status: unhealthy Condition: Schizophrenia Sources: Page: p.6 |
Overview
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
no | |||
Page: 18.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
yes | yes (co-administration study) Comment: administration of ketoconazole (CYP3A4 inhibitor) increased AUC of iloperidone by 57%; administration with paroxetine AND ketoconazole resulted in a 1.4 fold increase in steady-state concentration of iloperidone; Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
yes | yes (pharmacogenomic study) Comment: pharmacogenic study?; administration of fluoxetine (potent inhibitor of CYP2D6) increased AUC of iloperidone by about 2- to 3-fold; administration of paroxetine (potent inhibitor of CYP2D6) increased mean steady-state peak concentrations of iloperidone by about 1.6 fold; administration with paroxetine AND ketoconazole resulted in a 1.4 fold increase in steady-state concentration of iloperidone; Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022192s018s021lbl.pdf#page=15 Page: 15.0 |
Tox targets
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022192s000_PharmR_P1.pdf#page=30 Page: 30.0 |
PubMed
Title | Date | PubMed |
---|---|---|
3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873). | 1995 Mar 31 |
|
Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders. | 2001 Dec |
|
Iloperidone (Novartis). | 2002 Jan |
|
Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm. | 2003 Sep |
|
Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies. | 2008 Apr |
|
Long-term efficacy and safety of iloperidone: results from 3 clinical trials for the treatment of schizophrenia. | 2008 Apr |
|
Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials. | 2008 Apr |
|
Gateways to clinical trials. July-August 2008. | 2008 Jul-Aug |
|
Genome-wide association studies in pharmacogenomics: untapped potential for translation. | 2009 Apr 28 |
|
Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. | 2009 Aug |
|
Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. | 2009 Jun |
|
Akathisia and second-generation antipsychotic drugs. | 2009 May |
|
Iloperidone for the treatment of schizophrenia. | 2010 Aug |
|
A review of new atypical antipsychotic launches in the United States. | 2010 Dec |
|
New antipsychotic drugs: how do their receptor-binding profiles compare? | 2010 Sep |
|
Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults. | 2013 Jan |
Sample Use Guides
The recommended target dosage is 12 to 24 mg/day administered twice daily. This target dosage range is achieved by daily dosage adjustments, alerting patients to symptoms of orthostatic hypotension, starting at a dose of 1 mg twice daily, then moving to 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, and 12 mg twice daily on Days 2, 3, 4, 5, 6, and 7 respectively, to reach the 12 mg/day to 24 mg/day dose range.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22465688
While pacing the hearts at stimulation cycle lengths of 200 or 250 ms, or during natural sinus rhythm (no external pacing), iloperidone 100 nmol/L prolonged MAPD(90) by respectively 9.2 ± 0.9, 11.2 ± 1.6 and 21.4 ± 2.3 ms.
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Classification Tree | Code System | Code | ||
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NDF-RT |
N0000175430
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LIVERTOX |
NBK548669
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WHO-VATC |
QN05AX14
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NCI_THESAURUS |
C29710
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WHO-ATC |
N05AX14
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65173
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DB04946
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SUB08135MIG
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Iloperidone
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Iloperidone
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CHEMBL14376
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7045
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m6211
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C83784
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8207
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73178
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C081732
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EE-25
Created by
admin on Fri Dec 15 15:41:40 GMT 2023 , Edited by admin on Fri Dec 15 15:41:40 GMT 2023
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VPO7KJ050N
Created by
admin on Fri Dec 15 15:41:40 GMT 2023 , Edited by admin on Fri Dec 15 15:41:40 GMT 2023
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3294
Created by
admin on Fri Dec 15 15:41:40 GMT 2023 , Edited by admin on Fri Dec 15 15:41:40 GMT 2023
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87
Created by
admin on Fri Dec 15 15:41:40 GMT 2023 , Edited by admin on Fri Dec 15 15:41:40 GMT 2023
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ACTIVE MOIETY
METABOLITE (PARENT)
METABOLITE (PARENT)
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