Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C24H36NO2.Br |
| Molecular Weight | 450.452 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Br-].CC(C)[N@+]1(C)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(C3CCCC3)C4=CC=CC=C4
InChI
InChIKey=WEUHJSOYWODZCN-ZHRHLSBQSA-M
InChI=1S/C24H36NO2.BrH/c1-17(2)25(3)20-13-14-21(25)16-22(15-20)27-24(26)23(19-11-7-8-12-19)18-9-5-4-6-10-18;/h4-6,9-10,17,19-23H,7-8,11-16H2,1-3H3;1H/q+1;/p-1/t20-,21+,22+,23?,25?;
Ciclotropium is quaternary ammonium compound with anticholinergic and parasympatholytic activity. Oral Cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing adverse side effects. After cyclotropium bromide, there was a significant correlation between antral contraction amplitude and gastric emptying.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: Motil. Dig. Tract, [Proc. Int. Symp. Gastrointest. Motil.], 8th (1982), Meeting Date1981, 579-86.
Curator's Comment: The effect of 60 mg cyclotropium bromide, given orally, was compared with that of 60 mg scopolamine N-butylbromide and placebo on meal-stimulated motility of the distal colon in 24 healthy men with normal bowel function after an overnight fast; cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing adverse side effects, whereas scopolamine N-butylbromide exerted a weak inhibitory effect which was statistically indistinguishable from the effect of the placebo.
60 mg
Route of Administration:
Oral
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NCI_THESAURUS |
C66880
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SUB06252MIG
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ACTIVE MOIETY
SUBSTANCE RECORD
