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Details

Stereochemistry RACEMIC
Molecular Formula C22H25NO3.ClH
Molecular Weight 387.9
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PIPOXOLAN HYDROCHLORIDE

SMILES

Cl.O=C1OC(CCN2CCCCC2)OC1(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=JXNQXJVDHXGEPU-UHFFFAOYSA-N
InChI=1S/C22H25NO3.ClH/c24-21-22(18-10-4-1-5-11-18,19-12-6-2-7-13-19)26-20(25-21)14-17-23-15-8-3-9-16-23;/h1-2,4-7,10-13,20H,3,8-9,14-17H2;1H

HIDE SMILES / InChI

Description

Pipoxolan is an antispasmodic drug. In vivo, the drug inhibited the contractions of intestines caused by neostigmine, barium chloride or injection of acetylcholine. The drug possesses ganglioplegic action and inhibited the decrease in blood pressure caused by stimulation of the vagus nerve. The drug is marketed under tradename Rowapraxin worldwide for the treatment of spasms and colics in the gastrointestinal tract, gallbladder and urogenital area, bronchial spasms, spastic menstrual cramps. Recent studies have shown that pipoxalan has anticancer activity and inhibits proliferation of leukemia cells in animal models.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Modulator
828
PubMed

PubMed

TitleDatePubMed
Pipoxolan inhibits CL1-5 lung cancer cells migration and invasion through inhibition of MMP-9 and MMP-2.
2015 Jul 5
Patents

Patents

20070116729
157
7951398
20
WO2002045693A1
31
WO2010024870A1
59
Name Type Language
PIPOXOLAN HYDROCHLORIDE
MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
PIPOXOLAN HYDROCHLORIDE [MI]
Common Name English
PIPOXOLAN HYDROCHLORIDE [USAN]
Common Name English
BR-18
Code English
PIPOXOLAN HYDROCHLORIDE [MART.]
Common Name English
5,5-DIPHENYL-2-(2'-PIPERIDINOETHYL)-1,3-DIOXOLAN-4-ONE HYDROCHLORIDE
Common Name English
ROWAPRAXIN
Brand Name English
Pipoxolan hydrochloride [WHO-DD]
Common Name English
1,3-DIOXOLAN-4-ONE, 5,5-DIPHENYL-2-(2-(1-PIPERIDINYL)ETHYL)-, HYDROCHLORIDE
Systematic Name English
5,5-Diphenyl-2-(2-piperidinoethyl)-1,3-dioxolan-4-one hydrochloride
Systematic Name English
2-(.BETA.-N-PIPERIDYLETHYL)-4,4-DIPHENYL-1,3-DIOXOLAN-5-ONE HYDROCHLORIDE
Systematic Name English
1,3-DIOXOLAN-4-ONE, 5,5-DIPHENYL-2-(2-PIPERIDINOETHYL)-, HYDROCHLORIDE
Systematic Name English
1,3-DIOXOLAN-4-ONE, 5,5-DIPHENYL-2-(2-(1-PIPERIDINYL)ETHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
PIPOXOLAN HCL
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID5057672
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY
RXCUI
235861
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY RxNorm
CAS
18174-58-8
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY
PUBCHEM
28931
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY
SMS_ID
100000079705
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY
FDA UNII
VIA6WM647S
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY
EVMPD
SUB14896MIG
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY
NCI_THESAURUS
C170323
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110645
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY
MERCK INDEX
m8866
Created by admin on Fri Dec 15 16:53:16 GMT 2023 , Edited by admin on Fri Dec 15 16:53:16 GMT 2023
PRIMARY Merck Index
ACTIVE MOIETY
Structure of PIPOXOLAN
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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