PIPOXOLAN HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H25NO3.ClH
Molecular Weight	387.9
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O=C1OC(CCN2CCCCC2)OC1(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=JXNQXJVDHXGEPU-UHFFFAOYSA-N

InChI=1S/C22H25NO3.ClH/c24-21-22(18-10-4-1-5-11-18,19-12-6-2-7-13-19)26-20(25-21)14-17-23-15-8-3-9-16-23;/h1-2,4-7,10-13,20H,3,8-9,14-17H2;1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5440391 | https://www.epgonline.org/de/archivedrugs/rowapraxin-/ | https://www.ncbi.nlm.nih.gov/pubmed/21472325

Pipoxolan is an antispasmodic drug. In vivo, the drug inhibited the contractions of intestines caused by neostigmine, barium chloride or injection of acetylcholine. The drug possesses ganglioplegic action and inhibited the decrease in blood pressure caused by stimulation of the vagus nerve. The drug is marketed under tradename Rowapraxin worldwide for the treatment of spasms and colics in the gastrointestinal tract, gallbladder and urogenital area, bronchial spasms, spastic menstrual cramps. Recent studies have shown that pipoxalan has anticancer activity and inhibits proliferation of leukemia cells in animal models.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
regulation of relaxation of smooth muscle 3 Target ID: GO:1901080 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5440391	Modulator 846

PubMed

Title	Date	PubMed
Pipoxolan inhibits CL1-5 lung cancer cells migration and invasion through inhibition of MMP-9 and MMP-2.	2015-07-05	25899827

Patents

Name

Type

Language

ROWAPRAXIN

Preferred Name

English

PIPOXOLAN HYDROCHLORIDE

Official Name

English

PIPOXOLAN HYDROCHLORIDE [MI]

Common Name

English

PIPOXOLAN HYDROCHLORIDE [USAN]

Common Name

English

BR-18

Code

English

PIPOXOLAN HYDROCHLORIDE [MART.]

Common Name

English

5,5-DIPHENYL-2-(2'-PIPERIDINOETHYL)-1,3-DIOXOLAN-4-ONE HYDROCHLORIDE

Common Name

English

Pipoxolan hydrochloride [WHO-DD]

Common Name

English

1,3-DIOXOLAN-4-ONE, 5,5-DIPHENYL-2-(2-(1-PIPERIDINYL)ETHYL)-, HYDROCHLORIDE

Systematic Name

English

5,5-Diphenyl-2-(2-piperidinoethyl)-1,3-dioxolan-4-one hydrochloride

Systematic Name

English

2-(.BETA.-N-PIPERIDYLETHYL)-4,4-DIPHENYL-1,3-DIOXOLAN-5-ONE HYDROCHLORIDE

Systematic Name

English

1,3-DIOXOLAN-4-ONE, 5,5-DIPHENYL-2-(2-PIPERIDINOETHYL)-, HYDROCHLORIDE

Systematic Name

English

1,3-DIOXOLAN-4-ONE, 5,5-DIPHENYL-2-(2-(1-PIPERIDINYL)ETHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

PIPOXOLAN HCL

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID5057672