PARAMETHASONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H29FO5
Molecular Weight	392.4611
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=MKPDWECBUAZOHP-AFYJWTTESA-N

InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/paramethasone.html | https://www.ncbi.nlm.nih.gov/pubmed/839089 | https://books.google.ru/books?id=ihxyHbnj3qYC&printsec=frontcover&hl=ru#v=onepage&q&f=false

Paramethasone is a glucocorticoid. It exerts anti-inflammatory and immunosuppressant actions. Paramethasone stimulates the synthesis of enzymes needed to decrease anti-inflammatory response. It suppresses the immune system by reducing activity and volume of the lymphatic system, thus producing lymphocytopenia decreasing passage of immune complexes and possibly by depressing reactivity of tissue to antigen-antibody interactions.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
inflammatory response 47 Target ID: GO:0006954 Sources: Ebadi, M. (2007) Desk Reference of Clinical Pharmacology, page 543, retrieved from: https://books.google.ru/books?id=ihxyHbnj3qYC	Modulator 828

PubMed

Title	Date	PubMed
Two cases of specific adverse reactions to systemic corticosteroids.	1996 Sep-Oct	8959545
[Chronic adhesive arachnoiditis following epidural paramethasone].	1997 Dec	9528075
[Hiccups crisis following paramethasone intraarticular injection].	2005 Jun 25	15989860
Adalimumab for the treatment of fistulas in patients with Crohn's disease.	2009 Jul	19201775

Name

Type

Language

PARAMETHASONE

Official Name

English

PARAMETHASONE [VANDF]

Common Name

English

PARAMETHASONE [MI]

Common Name

English

(6.ALPHA.,11.BETA.,16.ALPHA.)-6-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE

Systematic Name

English

PARAMETHASONE [HSDB]

Common Name

English

DILLAR

Brand Name

English

Paramethasone [WHO-DD]

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 6-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-, (6.ALPHA.,11.BETA.,16.ALPHA.)-

Systematic Name

English

paramethasone [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH02AB05