U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C20H22ClN
Molecular Weight 311.8491
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYRROBUTAMINE

SMILES

c1ccc(cc1)C(=CCN2CCCC2)Cc3ccc(cc3)Cl

InChI

InChIKey=WDYYVNNRTDZKAZ-UHFFFAOYSA-N
InChI=1S/C20H22ClN/c21-20-10-8-17(9-11-20)16-19(18-6-2-1-3-7-18)12-15-22-13-4-5-14-22/h1-3,6-12H,4-5,13-16H2

HIDE SMILES / InChI
PYRROBUTAMINE is a potent H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate the inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Pyronil

Approved Use

Antihistaminic
PubMed

PubMed

TitleDatePubMed
Antihistaminic action of pyronil.
1952 Jul
Chemical and pharmacological characteristics of the antihistaminic compound, pyrrobutamine.
1953 Nov-Dec
Name Type Language
PYRROBUTAMINE
MI   WHO-DD  
Common Name English
PYRROBUTAMINE [WHO-DD]
Common Name English
1-(.GAMMA.-(P-CHLOROBENZYL)CINNAMYL)PYRROLIDINE
Common Name English
PYRROLIDINE, 1-(4-(4-CHLOROPHENYL)-3-PHENYL-2-BUTENYL)-
Systematic Name English
PYRROBUTAMINE [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
WHO-VATC QR06AX58
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
WHO-ATC R06AX08
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
WHO-ATC R06AX58
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
WHO-VATC QR06AX08
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
Code System Code Type Description
WIKIPEDIA
PYRROBUTAMINE
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
EPA CompTox
91-82-7
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
DRUG BANK
DB13846
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
DRUG CENTRAL
2334
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
CAS
91-82-7
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
NCI_THESAURUS
C81146
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
MESH
C013665
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
MERCK INDEX
M9396
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY Merck Index
ChEMBL
CHEMBL1697849
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
ECHA (EC/EINECS)
202-101-7
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
PUBCHEM
8669
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
EVMPD
SUB15066MIG
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY
FDA UNII
VE6KP18S8X
Created by admin on Sat Jun 26 01:01:44 UTC 2021 , Edited by admin on Sat Jun 26 01:01:44 UTC 2021
PRIMARY