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Details

Stereochemistry ACHIRAL
Molecular Formula C20H22ClN
Molecular Weight 311.848
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of PYRROBUTAMINE

SMILES

ClC1=CC=C(CC(=CCN2CCCC2)C3=CC=CC=C3)C=C1

InChI

InChIKey=WDYYVNNRTDZKAZ-UHFFFAOYSA-N
InChI=1S/C20H22ClN/c21-20-10-8-17(9-11-20)16-19(18-6-2-1-3-7-18)12-15-22-13-4-5-14-22/h1-3,6-12H,4-5,13-16H2

HIDE SMILES / InChI

Description

PYRROBUTAMINE is a potent H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate the inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria.

Approval Year

1952
115
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
Pyronil

Approved Use

Antihistaminic
Sourcing

Sourcing

Vendor/AggregatorIDURL
Alfa Chemistry
ACM28296642
Compound Cloud
5284614
Norris Pharm
NSZB-A030895
Toronto Research Chemicals
P997800
ZINC
ZINC000004474657
http://zinc15.docking.org/substances/ZINC000004474657
ZINC
ZINC000015848271
http://zinc15.docking.org/substances/ZINC000015848271
eMolecules
45955538
PubMed

PubMed

TitleDatePubMed
Antihistaminic action of pyronil.
1952 Jul
Chemical and pharmacological characteristics of the antihistaminic compound, pyrrobutamine.
1953 Nov-Dec
Name Type Language
PYRROBUTAMINE
MI   WHO-DD  
Common Name English
1-(.GAMMA.-(P-CHLOROBENZYL)CINNAMYL)PYRROLIDINE
Common Name English
Pyrrobutamine [WHO-DD]
Common Name English
PYRROLIDINE, 1-(4-(4-CHLOROPHENYL)-3-PHENYL-2-BUTENYL)-
Systematic Name English
PYRROBUTAMINE [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
WHO-VATC QR06AX58
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
WHO-ATC R06AX08
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
WHO-ATC R06AX58
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
WHO-VATC QR06AX08
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
Code System Code Type Description
SMS_ID
100000078935
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
WIKIPEDIA
PYRROBUTAMINE
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
EPA CompTox
DTXSID9023544
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
DRUG BANK
DB13846
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
DRUG CENTRAL
2334
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
CAS
91-82-7
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
NCI_THESAURUS
C81146
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
MESH
C013665
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
MERCK INDEX
m9396
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL1697849
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
ECHA (EC/EINECS)
202-101-7
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
PUBCHEM
8669
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
EVMPD
SUB15066MIG
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
FDA UNII
VE6KP18S8X
Created by admin on Fri Dec 15 15:18:14 UTC 2023 , Edited by admin on Fri Dec 15 15:18:14 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of PYRROBUTAMINE
SALT/SOLVATE (PARENT)
Structure of PYRROBUTAMINE PHOSPHATE
NIH
NCATS
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ACCESSIBILITY
DISCLAIMER
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