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Details

Stereochemistry ACHIRAL
Molecular Formula C14H10O5
Molecular Weight 258.2262
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SALSALATE

SMILES

OC(=O)C1=CC=CC=C1OC(=O)C2=CC=CC=C2O

InChI

InChIKey=WVYADZUPLLSGPU-UHFFFAOYSA-N
InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)

HIDE SMILES / InChI

Description

Salsalate is a dimer of salicylic acid. Upon administration, it is metabolically hydrolyzed to salicylic acid. Salsalate is is a nonsteroidal anti-inflammatory agent for oral administration for treatment of rheumatoid arthritis, osteoarthritis and related rheumatoid disorders. In addition, salsalate is investigated for treatment of type 2 diabetes.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
DISALCID
Palliative
DISALCID
Primary
Unknown

Cmax

ValueDoseCo-administeredAnalytePopulation
45 μg/mL
1500 mg single, oral
SALSALATE plasma
Homo sapiens
17 μg/mL
1500 mg single, oral
SALSALATE plasma
Homo sapiens
88 μg/mL
1500 mg single, oral
SALICYLIC ACID plasma
Homo sapiens
97 μg/mL
1500 mg single, oral
SALICYLIC ACID plasma
Homo sapiens
21.1 μg/mL
1000 mg single, oral
SALSALATE plasma
Homo sapiens
54.4 μg/mL
1000 mg single, oral
SALICYLIC ACID plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
101 μg × h/mL
1500 mg single, oral
SALSALATE plasma
Homo sapiens
50 μg × h/mL
1500 mg single, oral
SALSALATE plasma
Homo sapiens
847 μg × h/mL
1500 mg single, oral
SALICYLIC ACID plasma
Homo sapiens
1301 μg × h/mL
1500 mg single, oral
SALICYLIC ACID plasma
Homo sapiens
50 μg × h/mL
1000 mg single, oral
SALSALATE plasma
Homo sapiens
498 μg × h/mL
1000 mg single, oral
SALICYLIC ACID plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
1.2 h
1500 mg single, oral
SALSALATE plasma
Homo sapiens
2.1 h
1500 mg single, oral
SALSALATE plasma
Homo sapiens
3.8 h
1500 mg single, oral
SALICYLIC ACID plasma
Homo sapiens
8.1 h
1500 mg single, oral
SALICYLIC ACID plasma
Homo sapiens
1.1 h
1000 mg single, oral
SALSALATE plasma
Homo sapiens
3.5 h
1000 mg single, oral
SALICYLIC ACID plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
5%
SALICYLIC ACID serum
Homo sapiens

Doses

AEs

OverviewOther

Other InhibitorOther SubstrateOther Inducer







Drug as perpetrator​

Drug as victim

Tox targets

PubMed

Sample Use Guides

In Vivo Use Guide
The usual dosage is 3000 mg daily, given in divided doses as follows: 1(two doses of two 750 mg tablets; 2) two doses of three 500 mg tablets; or 3) three doses of two 500 mg tablets.
Route of Administration: Oral
In Vitro Use Guide
Unknown