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Details

Stereochemistry ACHIRAL
Molecular Formula C14H10O5
Molecular Weight 258.2262
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SALSALATE

SMILES

OC(=O)C1=CC=CC=C1OC(=O)C2=CC=CC=C2O

InChI

InChIKey=WVYADZUPLLSGPU-UHFFFAOYSA-N
InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/23817699 | https://www.ncbi.nlm.nih.gov/pubmed/6520777

Salsalate is a dimer of salicylic acid. Upon administration, it is metabolically hydrolyzed to salicylic acid. Salsalate is is a nonsteroidal anti-inflammatory agent for oral administration for treatment of rheumatoid arthritis, osteoarthritis and related rheumatoid disorders. In addition, salsalate is investigated for treatment of type 2 diabetes.

Originator

Approval Year

1995
196
Targets

Targets

Primary TargetPharmacologyConditionPotency
prostaglandin biosynthetic process
23
Target ID: GO:0001516
Sources: Salsalate selectively inhibits prostaglandin synthesis in vivo
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
DISALCID

Approved Use

Salsalate is indicated for relief of the signs and symptoms of rheumatoid arthritis, and related rheumatic disorder.
Palliative
Approved
8429
DISALCID

Approved Use

Salsalate is indicated for relief of the signs and symptoms of rheumatoid arthritis, osteoarthritis and related rheumatic disorder.
Primary
Phase III
656
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Modulation of endothelial cell activation in sickle cell disease: a pilot study.
2001 Apr 1
Lichenoid drug eruption to salsalate.
2001 Oct
Blood pressure elevation in a patient treated with salsalate.
2002 Apr
Nonsteroidal antiinflammatory drug starter packs for chronic musculoskeletal pain.
2002 Jul
Salicylic acid-induced inactivation of creatine kinase in the presence of lactoperoxidase and H2O2.
2005 Jan 15
Phenolic compounds, sodium salicylate and related compounds, as inhibitors of tumor cell growth and inducers of apoptosis in mouse leukemia L1210 cells.
2005 Jan-Feb
The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation.
2009 Sep
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Effects of salsalate therapy on recovery from vascular injury in female Zucker fatty rats.
2010 Dec
Potential role of salicylates in type 2 diabetes.
2010 Jul-Aug
Summaries for patients. The effects of salsalate on blood sugar control in people with type 2 diabetes.
2010 Mar 16
The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part III: Specific Management and Surgical Aspects.
2010 Nov
Wet oxidation of salicylic acid solutions.
2010 Nov 15
Patents

Patents

JP2001525058A
70
JP2007246450A
3
US922995
2

Sample Use Guides

In Vivo Use Guide
The usual dosage is 3000 mg daily, given in divided doses as follows: 1(two doses of two 750 mg tablets; 2) two doses of three 500 mg tablets; or 3) three doses of two 500 mg tablets.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
SALSALATE
USAN   INN  
Official Name English
DISALCID
Brand Name English
NSC-49171
Code English
DISALICYCLIC ACID
Common Name English
SASAPYRINE
JAN  
Common Name English
2-[(2-Hydroxybenzoyl)oxy]benzoic acid
Systematic Name English
CARBASALATE CALCIUM IMPURITY D [EP IMPURITY]
Common Name English
salsalate [INN]
Common Name English
SALSALATE [MI]
Common Name English
ACETYLSALICYLIC ACID IMPURITY E [EP IMPURITY]
Common Name English
BENZOIC ACID, 2-HYDROXY-, 2-CARBOXYPHENYL ESTER
Common Name English
SALSALATE [MART.]
Common Name English
SALSALATE [USAN]
Common Name English
SALICYLSALICYLIC ACID
Common Name English
Salsalate [WHO-DD]
Common Name English
DL-LYSINE ACETYLSALICYLATE IMPURITY M [EP IMPURITY]
Common Name English
SALSALATE [USP IMPURITY]
Common Name English
SALSALATE [USP-RS]
Common Name English
SASAPYRINE [JAN]
Common Name English
SALSALATE [VANDF]
Common Name English
SALICYLIC ACID, BIMOLECULAR ESTER
Common Name English
SALSALATE [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
WHO-ATC N02BA06
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
WHO-VATC QN02BA06
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
LIVERTOX NBK548843
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
NCI_THESAURUS C257
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
Code System Code Type Description
NSC
49171
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
LACTMED
Salsalate
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
SMS_ID
100000086562
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
CHEBI
9014
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
RXCUI
36108
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
209-027-4
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
ChEMBL
CHEMBL154111
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
DRUG BANK
DB01399
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
DRUG CENTRAL
2420
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
EVMPD
SUB10434MIG
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
PUBCHEM
5161
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
MERCK INDEX
m9747
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
SALSALATE
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
EPA CompTox
DTXSID1023572
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
INN
3267
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
FDA UNII
V9MO595C9I
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
DAILYMED
V9MO595C9I
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
MESH
C014182
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
CAS
552-94-3
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
RS_ITEM_NUM
1609807
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
NCI_THESAURUS
C62636
Created by admin on Fri Dec 15 15:10:17 GMT 2023 , Edited by admin on Fri Dec 15 15:10:17 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of SALSALATE
SALT/SOLVATE (PARENT)
Structure of SALSALATE SODIUM
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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