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Details

Stereochemistry ACHIRAL
Molecular Formula C13H11ClN2O2
Molecular Weight 262.6921
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLONIXIN

SMILES

Cc1c(cccc1Nc2c(cccn2)C(=O)O)Cl

InChI

InChIKey=CLOMYZFHNHFSIQ-UHFFFAOYSA-N
InChI=1S/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18)

HIDE SMILES / InChI
Clonixin is a nonsteroidal agent. It is an anilino-nicotinic acid derivative. It is a drug of anti-inflammatory antipyretic and analgesic activity that produces minor digestive side-effects. At high concentrations, clonixin inhibited PGE2 formed by COX-2 and partly by COX-1 activity. The drug is indicated for the relief of headaches, muscle aches, joint, dental, ear, dysmenorrhea, post-traumatic, post-surgical, gynecological. Adverse effects are occasionally nausea, dizziness, and somnolence, were mild and transient. On rare occasions, and administering high doses, it is possible the appearance of dry mouth or constipation. Concomitant use of anticholinergic drugs to be avoided by the possibility that they enhance their effects atropine.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Dorixina

Approved Use

Indicated for relief of headaches, muscle aches, joint, dental, ear, dysmenorrhea, post-traumatic, post-surgical, gynecological.
Palliative
Dorixina

Approved Use

Indicated for relief of headaches, muscle aches, joint, dental, ear, dysmenorrhea, post-traumatic, post-surgical, gynecological.
Primary
Dorixina

Approved Use

Indicated for relief of headaches, muscle aches, joint, dental, ear, dysmenorrhea, post-traumatic, post-surgical, gynecological.
PubMed

PubMed

TitleDatePubMed
Pharmacodynamics of flunixin and ketoprofen in mallard ducks (Anas platyrhynchos).
2001 Jun
Investigation of factors affecting pregnancy rate after embryo transfer in the dromedary camel.
2002
Non-surgical management of rectal tears in two mares.
2002 Mar
Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned thoroughbred horses subjected to an incremental exercise stress test.
2002 Spring
A comparative study of the effects of meloxicam and flunixin meglumine (NSAIDs) as adjunctive therapy on interferon and tumor necrosis factor production in calves suffering from enzootic bronchopneumonia.
2003
Role of prostaglandins in the development of hyperthermia in heat-stressed, lactating Holstein cows.
2003 Dec
Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B.
2003 Feb
Atropine reverses the antinociception of nonsteroidal anti-inflammatory drugs in the tail-flick test of mice.
2003 Feb
Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species.
2003 Jan
Residue depletion study and withdrawal period for flunixin-N-methyl glucamine in bovine milk following intravenous administration.
2003 Jul 30
Determination and confirmation of 5-hydroxyflunixin in raw bovine milk using liquid chromatography tandem mass spectrometry.
2003 Jun 18
Clinical efficacy of flunixin, carprofen and ketoprofen as adjuncts to the antibacterial treatment of bovine respiratory disease.
2003 Mar 29
Effect of morphine and flunixin meglumine on isoflurane minimum alveolar concentration in goats.
2004 Apr
Effects of two anti-inflammatory drugs on physiologic variables and milk production in cows with endotoxin-induced mastitis.
2004 Jan
Clinical efficacy of meloxicam (Metacam) and flunixin (Finadyne) as adjuncts to antibacterial treatment of respiratory disease in fattening cattle.
2004 Jul-Aug
Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia.
2004 Jun
Disposition of flunixin meglumine injectable preparation administered orally to healthy horses.
2004 Jun
Quantification and confirmation of flunixin in equine plasma by liquid chromatography-quadrupole time-of-flight tandem mass spectrometry.
2004 Mar 5
[Slaughter emergency].
2004 Nov 1
Effects of ischemia and the cyclooxygenase inhibitor flunixin on in vitro passage of lipopolysaccharide across equine jejunum.
2004 Oct
Field evaluation of flunixin meglumine in the supportive treatment of caprine mastitis.
2004 Oct
Effect of anti-inflammatory drugs on splenocyte membrane fluidity.
2005 Apr 1
Lysine clonixinate vs naproxen sodium for the acute treatment of migraine: a double-blind, randomized, crossover study.
2005 Dec 14
Evaluating postoperative analgesics in mice using telemetry.
2005 Feb
Use of force plate analysis to compare the analgesic effects of intravenous administration of phenylbutazone and flunixin meglumine in horses with navicular syndrome.
2005 Feb
Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl.
2005 Feb
Effects of cyclooxygenase inhibitors flunixin and deracoxib on permeability of ischaemic-injured equine jejunum.
2005 Jan
COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.
2005 Oct
Equine herpes myeloencephalopathy in a 12-year-old American quarter horse.
2006 Apr
Malabsorptive maldigestive disorder with concurrent Salmonella in a 3-year-old quarter horse.
2006 Apr
Acute diarrhea in the adult horse: case example and review.
2006 Apr
Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits.
2006 Jan
Questions dosage used in equine study.
2006 May
Effects of flunixin meglumine on selected clinicopathologic variables, and serum testosterone concentration in stallions after endotoxin administration.
2006 Sep
Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in ICR mice.
2007 Apr
Treatment of acute puerperal metritis with flunixin meglumine in addition to antibiotic treatment.
2007 Aug
FDA issues reminder on correct use of flunixin meglumine.
2007 Jul 1
Effects of flunixin meglumine and transportation on establishment of pregnancy in beef cows.
2007 Jun
Evaluation of the renal effects of flunixin meglumine, ketoprofen and meloxicam in budgerigars (Melopsittacus undulatus).
2007 Jun 16
Rapid method for the determination of non-steroidal anti-inflammatory drugs in animal tissue by liquid chromatography-mass spectrometry with ion-trap detector.
2007 Mar 14
Effect of the administration of flunixin meglumine on pregnancy rates in Holstein heifers.
2007 Mar 24
Outcome of medical and surgical treatment of cecal impaction in horses: 114 cases (1994-2004).
2007 Nov 1
Effect of flunixin meglumine on cytokine levels in experimental endotoxemia in mice.
2007 Sep
Effectiveness of administration of phenylbutazone alone or concurrent administration of phenylbutazone and flunixin meglumine to alleviate lameness in horses.
2008 Feb
Effect of preoperative administration of erythromycin or flunixin meglumine on postoperative abomasal emptying rate in dairy cows undergoing surgical correction of left displacement of the abomasum.
2008 Feb 1
Escherichia coli mastitis in cattle being treated for Staphylococcus aureus intramammary infection.
2008 Feb 2
Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.
2008 Jun
Flunixin horse pill use in human associated with peptic ulcer disease.
2008 Mar
Extralabel use of nonsteroidal anti-inflammatory drugs in cattle.
2008 Mar 1
Pharmacokinetics of enrofloxacin and flunixin meglumine and interactions between both drugs after intravenous co-administration in healthy and endotoxaemic rabbits.
2008 Sep
Patents

Sample Use Guides

200 mg single dose
Route of Administration: Intravenous
In Vitro Use Guide
clonixin (Clx) between 1 x 10(-6) M and 3 x 10(-4) M, decreases the overshoot (OS), action potential amplitude (APA), Vmax and frequency of primary and subsidiary cells, however pacemaker cells differ in their sensitivity to Clx. At 2 x 10(-6) M, Clx completely blocked the spontaneous beating of primary cells.
Name Type Language
CLONIXIN
INN   MART.   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
3-PYRIDINECARBOXYLIC ACID, 2-((3-CHLORO-2-METHYLPHENYL)AMINO)-
Common Name English
CLONIXIN [MI]
Common Name English
CLONIXIN [WHO-DD]
Common Name English
SCH 10304
Code English
2-(3-CHLORO-O-TOLUIDINO)NICOTINIC ACID
Common Name English
CLONIXIN [INN]
Common Name English
NSC-335505
Code English
CLONIXIN [USAN]
Common Name English
CLONIXIN [MART.]
Common Name English
SCH-10304
Code English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
Code System Code Type Description
EPA CompTox
17737-65-4
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
PUBCHEM
28718
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
CAS
17737-65-4
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
FDA UNII
V7DXN0M42R
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
WIKIPEDIA
CLONIXIN
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
RXCUI
2601
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY RxNorm
NCI_THESAURUS
C65340
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
INN
2718
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
DRUG BANK
DB09218
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
ECHA (EC/EINECS)
241-730-1
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
EVMPD
SUB06734MIG
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
MERCK INDEX
M3651
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY Merck Index
DRUG CENTRAL
705
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
ChEMBL
CHEMBL1332971
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY