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Details

Stereochemistry ACHIRAL
Molecular Formula C13H11ClN2O2
Molecular Weight 262.6921
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLONIXIN

SMILES

Cc1c(cccc1Nc2c(cccn2)C(=O)O)Cl

InChI

InChIKey=CLOMYZFHNHFSIQ-UHFFFAOYSA-N
InChI=1S/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18)

HIDE SMILES / InChI
Clonixin is a nonsteroidal agent. It is an anilino-nicotinic acid derivative. It is a drug of anti-inflammatory antipyretic and analgesic activity that produces minor digestive side-effects. At high concentrations, clonixin inhibited PGE2 formed by COX-2 and partly by COX-1 activity. The drug is indicated for the relief of headaches, muscle aches, joint, dental, ear, dysmenorrhea, post-traumatic, post-surgical, gynecological. Adverse effects are occasionally nausea, dizziness, and somnolence, were mild and transient. On rare occasions, and administering high doses, it is possible the appearance of dry mouth or constipation. Concomitant use of anticholinergic drugs to be avoided by the possibility that they enhance their effects atropine.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Dorixina

Approved Use

Indicated for relief of headaches, muscle aches, joint, dental, ear, dysmenorrhea, post-traumatic, post-surgical, gynecological.
Palliative
Dorixina

Approved Use

Indicated for relief of headaches, muscle aches, joint, dental, ear, dysmenorrhea, post-traumatic, post-surgical, gynecological.
Primary
Dorixina

Approved Use

Indicated for relief of headaches, muscle aches, joint, dental, ear, dysmenorrhea, post-traumatic, post-surgical, gynecological.
PubMed

PubMed

TitleDatePubMed
Pharmacokinetics of flunixin in the cat: enterohepatic circulation and active transport mechanism in the liver.
2004 Apr
Clinical efficacy of meloxicam (Metacam) and flunixin (Finadyne) as adjuncts to antibacterial treatment of respiratory disease in fattening cattle.
2004 Jul-Aug
Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia.
2004 Jun
Disposition of flunixin meglumine injectable preparation administered orally to healthy horses.
2004 Jun
[Slaughter emergency].
2004 Nov 1
Effects of ischemia and the cyclooxygenase inhibitor flunixin on in vitro passage of lipopolysaccharide across equine jejunum.
2004 Oct
Field evaluation of flunixin meglumine in the supportive treatment of caprine mastitis.
2004 Oct
Effect of anti-inflammatory drugs on splenocyte membrane fluidity.
2005 Apr 1
Lysine clonixinate vs naproxen sodium for the acute treatment of migraine: a double-blind, randomized, crossover study.
2005 Dec 14
Evaluating postoperative analgesics in mice using telemetry.
2005 Feb
Use of force plate analysis to compare the analgesic effects of intravenous administration of phenylbutazone and flunixin meglumine in horses with navicular syndrome.
2005 Feb
Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl.
2005 Feb
Effects of cyclooxygenase inhibitors flunixin and deracoxib on permeability of ischaemic-injured equine jejunum.
2005 Jan
Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in dogs.
2005 Jul
Technical Note: Improved technique for fitting pigs with steered ileocecal valve cannulas.
2005 Jul
Interaction of clonixin with EPC liposomes used as membrane models.
2005 Jun
Investigation of the effect of black walnut extract on in vitro ion transport and structure of equine colonic mucosa.
2005 Mar
COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.
2005 Oct
Effect of a CIDR insert and flunixin meglumine, administered at the time of embryo transfer, on pregnancy rate and resynchronization of estrus in beef cattle.
2005 Sep 1
Equine herpes myeloencephalopathy in a 12-year-old American quarter horse.
2006 Apr
Malabsorptive maldigestive disorder with concurrent Salmonella in a 3-year-old quarter horse.
2006 Apr
Acute diarrhea in the adult horse: case example and review.
2006 Apr
Postpartum hemoperitoneum and septic peritonitis in a Thoroughbred mare.
2006 Apr
Actinobacillus peritonitis in a Warmblood gelding.
2006 Apr
Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits.
2006 Jan
Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses.
2006 Mar
Efficacy of ceftiofur and flunixin in the early treatment of bronchopneumonia in weaners.
2006 Mar 4
Questions dosage used in equine study.
2006 May
Effects of cyclooxygenase inhibition on the gastrointestinal tract.
2006 Nov
Pharmacokinetics of flunixin meglumine in swine after intravenous dosing.
2006 Oct
Effects of flunixin meglumine on selected clinicopathologic variables, and serum testosterone concentration in stallions after endotoxin administration.
2006 Sep
Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in ICR mice.
2007 Apr
Treatment of acute puerperal metritis with flunixin meglumine in addition to antibiotic treatment.
2007 Aug
Suspected panosteitis in a camel.
2007 Aug 1
Outbreak of neurologic disease caused by equine herpesvirus-1 at a university equestrian center.
2007 Jan-Feb
Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum.
2007 Jun
Effects of flunixin meglumine and transportation on establishment of pregnancy in beef cows.
2007 Jun
Evaluation of the renal effects of flunixin meglumine, ketoprofen and meloxicam in budgerigars (Melopsittacus undulatus).
2007 Jun 16
The effect of a topical anaesthetic formulation, systemic flunixin and carprofen, singly or in combination, on cortisol and behavioural responses of Merino lambs to mulesing.
2007 Mar
In vitro effects of reactive oxygen metabolites, with and without flunixin meglumine, on equine colonic mucosa.
2007 Mar
Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs.
2007 Mar
Rapid method for the determination of non-steroidal anti-inflammatory drugs in animal tissue by liquid chromatography-mass spectrometry with ion-trap detector.
2007 Mar 14
Effect of the administration of flunixin meglumine on pregnancy rates in Holstein heifers.
2007 Mar 24
Effect of flunixin meglumine on cytokine levels in experimental endotoxemia in mice.
2007 Sep
Effectiveness of administration of phenylbutazone alone or concurrent administration of phenylbutazone and flunixin meglumine to alleviate lameness in horses.
2008 Feb
Effect of preoperative administration of erythromycin or flunixin meglumine on postoperative abomasal emptying rate in dairy cows undergoing surgical correction of left displacement of the abomasum.
2008 Feb 1
Escherichia coli mastitis in cattle being treated for Staphylococcus aureus intramammary infection.
2008 Feb 2
Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.
2008 Jun
Flunixin horse pill use in human associated with peptic ulcer disease.
2008 Mar
Extralabel use of nonsteroidal anti-inflammatory drugs in cattle.
2008 Mar 1
Patents

Sample Use Guides

200 mg single dose
Route of Administration: Intravenous
In Vitro Use Guide
clonixin (Clx) between 1 x 10(-6) M and 3 x 10(-4) M, decreases the overshoot (OS), action potential amplitude (APA), Vmax and frequency of primary and subsidiary cells, however pacemaker cells differ in their sensitivity to Clx. At 2 x 10(-6) M, Clx completely blocked the spontaneous beating of primary cells.
Name Type Language
CLONIXIN
INN   MART.   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
3-PYRIDINECARBOXYLIC ACID, 2-((3-CHLORO-2-METHYLPHENYL)AMINO)-
Common Name English
CLONIXIN [MI]
Common Name English
CLONIXIN [WHO-DD]
Common Name English
SCH 10304
Code English
2-(3-CHLORO-O-TOLUIDINO)NICOTINIC ACID
Common Name English
CLONIXIN [INN]
Common Name English
NSC-335505
Code English
CLONIXIN [USAN]
Common Name English
CLONIXIN [MART.]
Common Name English
SCH-10304
Code English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
Code System Code Type Description
EPA CompTox
17737-65-4
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
PUBCHEM
28718
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
CAS
17737-65-4
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
FDA UNII
V7DXN0M42R
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
WIKIPEDIA
CLONIXIN
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
RXCUI
2601
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY RxNorm
NCI_THESAURUS
C65340
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
INN
2718
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
DRUG BANK
DB09218
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
ECHA (EC/EINECS)
241-730-1
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
EVMPD
SUB06734MIG
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
MERCK INDEX
M3651
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY Merck Index
DRUG CENTRAL
705
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY
ChEMBL
CHEMBL1332971
Created by admin on Sat Jun 26 14:56:43 UTC 2021 , Edited by admin on Sat Jun 26 14:56:43 UTC 2021
PRIMARY