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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C5H6NO3.Mg
Molecular Weight 280.5171
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAGNESIUM PIDOLATE

SMILES

[Mg++].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]2CCC(=O)N2

InChI

InChIKey=JQAACYUZYRBHGG-QHTZZOMLSA-L
InChI=1S/2C5H7NO3.Mg/c2*7-4-2-1-3(6-4)5(8)9;/h2*3H,1-2H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*3-;/m00./s1

HIDE SMILES / InChI
Zinc Pidolate (Zinc PCA) is a topical skin product with purifying, astingent, anti-inflammatory, antiseptic activity. It has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. Zinc Pidolate has also being shown to be effective against halitosis. Zinc PCA prevents the UV-induced MMP-1 production in vitro by suppressing the activation of AP-1. Zinc PCA was also able to enhance type I collagen synthesis in NHDFs, by increasing the expression of the mRNA encoding the ascorbic acid transporter SVCT2 in non-UV irradiated NHDFs, which suggests its promising effect against not only photoaged skin but also for the simple atrophic change of intrinsic skin ageing. Zinc PCA is able to suppress sebum secretion by inhibiting 5-α reductase in hyperseborrhea, to suppress body odor by forming zinc salts with short-chain fatty acids, to suppress wrinkles by inhibiting AP-1 to and inhibit bacterial growth including acne related Propionibacterium acnes.

CNS Activity

Curator's Comment: Known to penetrate blood-brain barrier in rats. Is produced naturally in human brain

Originator

Sources: Haitinger, L.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel

Approved Use

Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne.

Launch Date

2012
Primary
Unknown

Approved Use

Unknown
Primary
EcoCare™ Zinclean

Approved Use

Use in anti-dandruff shampoos
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
A simultaneous assay method for L-glutamate and L-pyroglutamate contents in soy sauce using a 5-oxoprolinase (without ATP hydrolyzing activity).
2001 Feb
Stability and CTL activity of N-terminal glutamic acid containing peptides.
2001 Jun
The X-ray crystal structure of pyrrolidone-carboxylate peptidase from hyperthermophilic archaea Pyrococcus horikoshii.
2002
Expression and prognostic significance of lysozyme in male breast cancer.
2002
Comparison of the positive and negative ion electrospray mass spectra of some small peptides containing pyroglutamate.
2002
Continuous spectrometric assays for glutaminyl cyclase activity.
2002 Apr 1
Major outer membrane proteins and proteolytic processing of RgpA and Kgp of Porphyromonas gingivalis W50.
2002 Apr 1
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.
2002 Apr 2
The primary structure of cassowary (Casuarius casuarius) goose type lysozyme.
2002 Jan
Pseudopeptide foldamers: the homo-oligomers of pyroglutamic acid.
2002 Jun 3
Five- and six-membered ring opening of pyroglutamic diketopiperazine.
2002 Mar 22
Synthesis and preliminary evaluation of trans-3,4-conformationally-restricted glutamate and pyroglutamate analogues as novel EAAT2 inhibitors.
2002 Nov 4
Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity.
2002 Sep 3
Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site.
2004 Feb 10
Unexplained metabolic acidosis in critically ill patients: the role of pyroglutamic acid.
2004 Mar
Mass spectrometric analysis of posttranslational modifications of a carrot extracellular glycoprotein.
2004 May 25
Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).
2004 Sep
Nanoparticles on the basis of highly functionalized dextrans.
2005 Aug 3
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.
2005 Jul
Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).
2005 Jul
Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides.
2005 May
Patents

Sample Use Guides

In Vivo Use Guide
Sources: Topical, as a compontent of lotions, creams and other cosmetic products.
Topical, as a compontent of lotions, creams and other cosmetic products.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Name Type Language
MAGNESIUM PIDOLATE
EP   MART.   WHO-DD  
Common Name English
MAGNESIUM PIDOLATE [MART.]
Common Name English
Magnesium pidolate [WHO-DD]
Common Name English
MAGNESIUM PCA
INCI  
INCI  
Official Name English
PIDOLIC ACID MAGNESIUM SALT (2:1)
Common Name English
MAGNESIUM PCA [INCI]
Common Name English
L-PROLINE, 5-OXO-, MAGNESIUM SALT (2:1)
Common Name English
MAGNESIUM PIDOLATE [EP MONOGRAPH]
Common Name English
MAGNESIUM PYROGLUTAMATE
Common Name English
Classification Tree Code System Code
WHO-VATC QA12CC08
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
WHO-ATC A12CC08
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
Code System Code Type Description
WIKIPEDIA
MAGNESIUM PIDOLATE
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
DRUG BANK
DBSALT002689
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL397976
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
FDA UNII
V5PC588N7G
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
DAILYMED
V5PC588N7G
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
PUBCHEM
14559042
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
SMS_ID
100000089075
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
RXCUI
116240
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY RxNorm
DRUG CENTRAL
4597
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
ECHA (EC/EINECS)
263-365-7
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
EVMPD
SUB03045MIG
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY
CAS
62003-27-4
Created by admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
PRIMARY