Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H12O5 |
Molecular Weight | 212.1993 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(=CC(OC)=C1OC)C(O)=O
InChI
InChIKey=SJSOFNCYXJUNBT-UHFFFAOYSA-N
InChI=1S/C10H12O5/c1-13-7-4-6(10(11)12)5-8(14-2)9(7)15-3/h4-5H,1-3H3,(H,11,12)
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/21959301Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21780738 | https://www.ncbi.nlm.nih.gov/pubmed/18404310
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21959301
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21780738 | https://www.ncbi.nlm.nih.gov/pubmed/18404310
3,4,5-Trimethoxybenzoic acid was used as internal standard during the determination of the various types of hydroxyl groups present in lignins. 3,4,5-Trimethoxybenzoic Acid is a metabolite of trimebutine. It is widely used in making dyes and inks, photographic developers and used as astringents in medically.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:0002119 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21780738 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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[Calcium oscillations induced by lindane in peritoneal macrophages of mice: control by the maturation stage of the macrophage]. | 2001 |
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Tumor necrosis factor-alpha induces distinctive NF-kappa B signaling within human dermal fibroblasts. | 2001 Mar 2 |
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Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes. | 2001 Nov |
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Glycine blocks the increase in intracellular free Ca2+ due to vasoactive mediators in hepatic parenchymal cells. | 2002 Dec |
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Characterization of tropane alkaloid aromatic esters that reverse the multidrug-resistance phenotype. | 2002 May-Jun |
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Quantitative determination of trimebutine maleate and its three metabolites in human plasma by liquid chromatography-tandem mass spectrometry. | 2002 Nov 5 |
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Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds. | 2003 Jun 20 |
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Trypanocidal tetrahydrofuran lignans from inflorescences of Piper solmsianum. | 2003 Sep |
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DdAlix, an Alix/AIP1 homolog in Dictyostelium discoideum, is required for multicellular development under low Ca2+ conditions. | 2004 Aug 4 |
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Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats. | 2004 Nov 16 |
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Type-3 ryanodine receptor involved in Ca2+-induced Ca2+ release and transmitter exocytosis at frog motor nerve terminals. | 2005 Dec |
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[Interaction of tropoxin and its molecular fragments tropan and 3,4,5-trimethoxybenzoate with serotonin receptors of cortical neurons in the rat brain (a microionophoretic study)]. | 2005 Jul-Aug |
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Thermally assisted hydrolysis and methylation of purified tannins from plants. | 2005 Sep 1 |
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Macrophage migration inhibitory factor induces cell death and decreases neuronal nitric oxide expression in spinal cord neurons. | 2006 |
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3,4-Dihydroxy-phenyl 3,4,5-trimethoxy-benzoate. | 2007 Dec 6 |
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3,6-Bis(3,4,5-trimethoxy-phen-yl)-1,2,4-triazolo[3,4-b][1,3,4]thia-diazole. | 2008 Jul 23 |
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N-(3,4-Difluoro-phen-yl)-3,4,5-trimethoxy-benzamide. | 2010 Apr 24 |
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Asymmetric localization of Arabidopsis SYP124 syntaxin at the pollen tube apical and sub-apical zones is involved in tip growth. | 2010 Aug 18 |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21780738
A soil sample (500 g) was collected from pure culture of H. zeae, maintained on maize plants (CWM-19), the commercially available cultivar, in microplots of a screen house, National Nematological Research Centre, University of Karachi. The emerged larvae were collected from the soil by Baermann funnel technique. After larvae had been counted in a counting chamber, 100 larvae were placed in a cavity block with a minimum amount of water for bioassayFor the pure compounds, 1 mg/mL was the stock solution (3,4,5-Trimethoxybenzoic Acid in DMSO)), and 1.0, 0.5, 0.25, and 0.125% dilutions were prepared from the stock. The standard nematicide carbofuran was used for the comparison, and distilled water was used as the control. Stock solution of positive control, that is, carbofuran was also prepared in the same manner as for extracts and pure compounds. The nematicidal activities of 5% dimethyl sulfoxide (DMSO) and 5% methanol used as the solvent and as negative controls were also determine. To determine the nematicidal effect of methanol and DMSO soluble fractions and pure compounds, 100 freshly hatched second-stage juveniles were introduced separately in each 3 x 3 glass Petri plates with the three replicates. Petri plates were kept at room temperature (28 +/- 2 C) in the laboratory and dark box conditions. Each treatment was observed in light and dark conditions separately and replicated three times. The mortality of the nematodes was examined under a stereoscopic microscope at 4C after 24 h. In the case of immobile larvae, their irreversible immobility was confirmed by transferring them to distilled water. The percent mortality was calculated from an average of three replicates (N = 3). This procedure was repeated after 48 and 72 h.
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SUBSTANCE RECORD