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Details

Stereochemistry ACHIRAL
Molecular Formula C9H19NO2
Molecular Weight 173.2527
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TEMPOL-H

SMILES

CC1(C)CC(O)CC(C)(C)N1O

InChI

InChIKey=CSGAUKGQUCHWDP-UHFFFAOYSA-N
InChI=1S/C9H19NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11-12H,5-6H2,1-4H3

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.
2003-02-07
Metabolic activation of 3-hydroxyanisole by isolated rat hepatocytes.
2003-01-06
A low molecular weight antioxidant decreases weight and lowers tumor incidence.
2003-01-01
The effect of lipophilicity of spin-labeled compounds on their distribution in solid lipid nanoparticle dispersions studied by electron paramagnetic resonance.
2003-01
Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension.
2003-01
Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency.
2003-01
Study of release kinetics of small and high molecular weight substances dispersed into spray-dried ethylcellulose microspheres.
2002-12-05
TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney.
2002-12-01
Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling.
2002-12
A mouse model of angiotensin II slow pressor response: role of oxidative stress.
2002-12
Increased renal vascular resistance in zinc-deficient rats: role of nitric oxide and superoxide.
2002-12
Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.
2002-11-14
Early antioxidant therapy with Tempol during hemorrhagic shock increases survival in rats.
2002-11
Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats: role of reactive oxygen species.
2002-11
Superoxide stimulates NaCl absorption by the thick ascending limb.
2002-11
Identification by an EPR technique of decreased mitochondrial reducing activity in puromycin aminonucleoside-induced nephrosis.
2002-10-15
Hepatic redox regulation of transcription factors activator protein-1 and nuclear factor-kappaB after hemorrhagic shock in vivo.
2002-10
Influence of different radioprotective compounds on radiotolerance and cell cycle distribution of human progenitor cells of granulocytopoiesis in vitro.
2002-10
Lipoteichoic acid from Staphylococcus aureus reduces renal ischemia/reperfusion injury.
2002-10
Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats.
2002-09
In vivo bioassays of acute asbestosis and its correlation with ESR spectroscopy and imaging in redox status.
2002-08-07
Nitroxides as antioxidants: Tempol protects against EO9 cytotoxicity.
2002-08-07
Analysis of tert-butyl hydroperoxide induced constrictions of perfused vascular beds in vitro.
2002-08-02
The nitroxide antioxidant tempol is cerebroprotective against focal cerebral ischemia in spontaneously hypertensive rats.
2002-08
Tiron exerts effects unrelated to its role as a scavenger of superoxide anion: effects on calcium binding and vascular responses.
2002-08
Kinetics and mechanism of hydroxyl radical and OH-adduct radical reactions with nitroxides and with their hydroxylamines.
2002-07-24
Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases?
2002-07-05
The effects of derivatives of the nitroxide tempol on UVA-mediated in vitro lipid and protein oxidation.
2002-07-01
Tempol selectively attenuates angiotensin II evoked vasoconstrictor responses in spontaneously hypertensive rats.
2002-07
Angiotensin II, the endothelium and superoxide anions.
2002-07
Zn deficiency aggravates hypertension in spontaneously hypertensive rats: possible role of Cu/Zn-superoxide dismutase.
2002-07
Low-dose doxorubicin-induced necrosis in Jurkat cells and its acceleration and conversion to apoptosis by antioxidants.
2002-07
Impaired regulation of renal oxygen consumption in spontaneously hypertensive rats.
2002-07
Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia.
2002-05-15
Motility and fertility of bull sperm in whole milk extender containing antioxidants.
2002-05-15
Time window of nitroxide effect on myocardial ischemic-reperfusion injury potentiated by iron.
2002-05-01
The altered balance between sympathetic nervous system and nitric oxide in salt hypertensive Dahl rats: ontogenetic and F2 hybrid studies.
2002-05
Nitric oxide-mediated depletion of Langerhans cells from the epidermis may be involved in UVA radiation-induced immunosuppression.
2002-05
O2 penetration and proton burial depth in proteins: applicability to fold family recognition.
2002-04-24
Polynitroxyl-albumin (PNA) enhances myocardial infarction therapeutic effect of tempol in rat hearts subjected to regional ischemia-reperfusion.
2002-04-15
The influence of additives on beer stability investigated by EPR spectroscopy.
2002-04
The Mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species.
2002-04
Cerebral resuscitation potentials for cardiac arrest.
2002-04
Lack of impairment of nitric oxide-mediated responses in a rat model of high-renin hypertension.
2002-03-22
Altered balance of main vasopressor and vasodepressor systems in rats with genetic hypertension and hypertriglyceridaemia.
2002-03
Polynitroxylated starch/TPL attenuates cachexia and increased epithelial permeability associated with TNBS colitis.
2002-02
Mechanism by which superoxide potentiates tubuloglomerular feedback.
2002-02
Interaction of O(2)(-) and NO in the thick ascending limb.
2002-02
Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis.
2002
The formation of an inverted hexagonal phase from thylakoid membranes upon heating.
2002
Patents
Name Type Language
TEMPOL-H
Common Name English
OT-674
Preferred Name English
4-PIPERIDINOL, 1-HYDROXY-2,2,6,6-TETRAMETHYL-
Systematic Name English
4-HYDROXY-2,2,6,6-TETRAMETHYL-N-HYDROXYPIPERIDINE
Systematic Name English
Code System Code Type Description
CAS
3637-10-3
Created by admin on Mon Mar 31 21:14:30 GMT 2025 , Edited by admin on Mon Mar 31 21:14:30 GMT 2025
PRIMARY
EPA CompTox
DTXSID40859711
Created by admin on Mon Mar 31 21:14:30 GMT 2025 , Edited by admin on Mon Mar 31 21:14:30 GMT 2025
PRIMARY
FDA UNII
V55XB6IT82
Created by admin on Mon Mar 31 21:14:30 GMT 2025 , Edited by admin on Mon Mar 31 21:14:30 GMT 2025
PRIMARY
PUBCHEM
5395
Created by admin on Mon Mar 31 21:14:30 GMT 2025 , Edited by admin on Mon Mar 31 21:14:30 GMT 2025
PRIMARY