Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H4O7 |
| Molecular Weight | 200.1025 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC(=O)C(O)=C(O1)C(O)=O
InChI
InChIKey=ZEGRKMXCOCRTCS-UHFFFAOYSA-N
InChI=1S/C7H4O7/c8-2-1-3(6(10)11)14-5(4(2)9)7(12)13/h1,9H,(H,10,11)(H,12,13)
Poppy acid occurs in opium (Papaver somniferum) and other Papaver species. Meconic acid has been described as a mild narcotic, but it has little or no physiological action, and is not now used medicinally. Its chemical reactions are of importance in toxicology as a valuable indication of the presence of opium.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric analysis of opiates and metabolites in rat urine after inhalation of opium. | 2003 Jun 5 |
|
| The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase. | 2004 Jun 21 |
|
| HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis. | 2004 Oct 21 |
|
| Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase. | 2010 Dec 21 |
Patents
Sample Use Guides
Dogs: Meconic acid, taken in a dose of from eight to ten grains, produces no sensible effect upon young and week dogs.
Route of Administration:
Oral
Effects of comenic and meconic acids on cultured dorsal root ganglion cells were investigated by the whole-cell patch clamp technique. The acids decreased effective charge transfer in the activation gating system of TTX-resistant (slow) sodium channels in a dose-dependent manner. The effects were described by Hill's equation. The dissociation constant and Hill coefficient values were K(D) = 100 nM and X = 0.5 (for comenic acid) and K(D) = 10 nM and X = 0.34 (for meconic acid).
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m7123
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V502I79516
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MECONIC ACID
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SUBSTANCE RECORD
