CHROMIUM GLUCONATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	3C6H11O7.Cr
Molecular Weight	637.4381
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 12
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cr+3].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=ANPGUZATXCGJJH-OPDGVEILSA-K

InChI=1S/3C6H12O7.Cr/c3*7-1-2(8)3(9)4(10)5(11)6(12)13;/h3*2-5,7-11H,1H2,(H,12,13);/q;;;+3/p-3/t3*2-,3-,4+,5-;/m111./s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10630581 | https://www.ncbi.nlm.nih.gov/pubmed/28954488

Chromium sulfate(III) hexahydrate or chromium sulphate, a trivalent compound of chromium that was investigated as a toxic compound. Experiments on rodent have shown chromium sulfate produced severe and widespread effects in the nasal cavity, larynx, lungs, and mediastinal lymph node. Effects were characterized by the accumulation of foreign material, infiltration of alveolar macrophages, septal cell hyperplasia, and granulomatous and chronic inflammation. Besides, chromium sulphate exerted a disadvantageous effect on the skeleton, as it decreases bone density and resistance.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
transmembrane receptor protein tyrosine kinase activity 22 Target ID: GO:0004714 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15924436	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Chromium deficiency 22 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4d01ebb-a36e-44b7-028c-43c0ab2d13b4	Preventing		Approved 8429	CHROMIUM Approved Use Chromium 4 mcg/mL (Chromic Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition. Administration helps to maintain chromium serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms. Launch Date 2005

PubMed

Title	Date	PubMed
Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin.	1994 Jun	8006454
Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity.	1996 Mar	8991630
Activation of MAPKs in human bronchial epithelial cells exposed to metals.	1998 Sep	9728050
Thirteen-week subchronic rat inhalation toxicity study with a recovery phase of trivalent chromium compounds, chromic oxide, and basic chromium sulfate.	1999 Dec	10630581
Status of antioxidant defense system in chromium-induced Swiss mice tissues.	2004 Jul	21782722
The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+.	2005 Dec 1	16274885
Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium.	2007 Aug	17606337
Effects of subchronic exposure via drinking water to a mixture of eight water-contaminating metals: a biochemical and histopathological study in male rats.	2007 Nov	17882470
Immunosuppressive effect of subchronic exposure to a mixture of eight heavy metals, found as groundwater contaminants in different areas of India, through drinking water in male rats.	2007 Oct	17657459
The peripheral quantitative computed tomographic and densitometric analysis of skeletal tissue in male Wistar rats after chromium sulfate treatment.	2017 Sep 21	28954488

Patents

Name

Type

Language

CHROMIUM GLUCONATE

Common Name

English

D-GLUCONIC ACID, CHROMIUM SALT

Common Name

English

CHROMIUM(III) GLUCONATE

Common Name

English

Code System Code Type Description

DAILYMED

V236ZVR3RL