Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H20BrN4O12PS |
Molecular Weight | 579.271 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(=O)(=O)OCCN(CCBr)C1=C(C=C(C=C1C(=O)NCCOP(O)(O)=O)[N+]([O-])=O)[N+]([O-])=O
InChI
InChIKey=GZSOKPMDWVRVMG-UHFFFAOYSA-N
InChI=1S/C14H20BrN4O12PS/c1-33(28,29)31-7-5-17(4-2-15)13-11(14(20)16-3-6-30-32(25,26)27)8-10(18(21)22)9-12(13)19(23)24/h8-9H,2-7H2,1H3,(H,16,20)(H2,25,26,27)
PR-104 is a phosphate ester dinitrobenzamide mustard pre-prodrug that is rapidly hydrolyzed systemically to PR-104A, a bioreductive prodrug. PR-104A is in turn activated via reduction by NADPH:cytochrome P450 oxidoreductase and other one-electron reductases in hypoxic cells, and by aldo-keto reductase 1C3 (AKR1C3) independently of oxygen, to the corresponding hydroxylamine (PR-104H) and amine (PR-104M) metabolites. Subsequently, these reactive nitrogen mustards crosslink DNA and cause cytotoxicity in cells. PR-104 is known to have preclinical anti-tumor activity in human tumor xenograft models as mono-therapy and in combination with radiotherapy and chemotherapy. Thrombocytopenia, and to a lesser extent neutropenia, was the dose-limiting toxicity of weekly PR-104. Combination of PR-104 with docetaxel or gemcitabine caused dose-limiting and severe myelotoxicity in patients with advanced solid tumors. PR-104 had been in phase II clinical trial for the treatment of acute myeloid leukemia.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients. | 2011 Oct 7 |
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The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104. | 2013 |
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Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia. | 2014 Feb |
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Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A. | 2018 Aug |
Patents
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NCI_THESAURUS |
C274
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V16D2ZT7DT
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PR-104
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DB05968
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11455973
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DTXSID001005607
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851627-62-8
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C61590
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SUBSTANCE RECORD