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Details

Stereochemistry ACHIRAL
Molecular Formula C13H18N2O3
Molecular Weight 250.2936
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEPTABARBITAL

SMILES

CCC1(C(=O)NC(=O)NC1=O)C2=CCCCCC2

InChI

InChIKey=PAZQYDJGLKSCSI-UHFFFAOYSA-N
InChI=1S/C13H18N2O3/c1-2-13(9-7-5-3-4-6-8-9)10(16)14-12(18)15-11(13)17/h7H,2-6,8H2,1H3,(H2,14,15,16,17,18)

HIDE SMILES / InChI

Description

HEPTABARBITAL is an intermediate or short term barbiturate. It binds to the GABAA receptor at either the alpha or the beta subunit. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. HEPTABARBITAL was formerly used as a sedative and hypnotic drug.

CNS Activity

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Medomin

Cmax

ValueDoseCo-administeredAnalytePopulation
1.94 mg/L
200 mg single, oral
HEPTABARBITAL plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
14.6 mg × h/L
200 mg single, oral
HEPTABARBITAL plasma
Homo sapiens
23.6 mg × h/L
200 mg single, oral
HEPTABARBITAL plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
7.7 h
200 mg single, oral
HEPTABARBITAL plasma
Homo sapiens

Doses

PubMed