SIMENEPAG

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H29NO5S
Molecular Weight	431.545
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC[C@H](O)C1=CC=C(C=C1)N2[C@@H](COCC3=CC=C(S3)C(O)=O)CCC2=O

InChI

InChIKey=NGKFLYGSJDSBQC-QUCCMNQESA-N

InChI=1S/C23H29NO5S/c1-2-3-4-5-20(25)16-6-8-17(9-7-16)24-18(10-13-22(24)26)14-29-15-19-11-12-21(30-19)23(27)28/h6-9,11-12,18,20,25H,2-5,10,13-15H2,1H3,(H,27,28)/t18-,20+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://adisinsight.springer.com/drugs/800030473 | http://www.freepatentsonline.com/y2007/0203222.htmlhttps://drugprofiles.informa.com/drug_profiles/18917-agn-210669 | https://www.drugbank.ca/drugs/DB12977

Simenepag isopropyl (AGN-210669) is an ophthalmic solution with potential intraocular pressure (IOP) lowering effects. Although the mechanism of action has not been disclosed, it is likely to be a sustained-release formulation of the EP agonist, AGN-210961. Simenepag isopropyl has been used in trials studying the treatment of ocular hypertension and open-angle glaucoma.

Originator

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

Drug: Simenepag isopropyl (AGN-210669) ophthalmic solution, 0.1% One drop of AGN-210669 ophthalmic solution, 0.1% in both eyes each evening from Day 1 through the evening prior to Day 29. Selected sites: One additional drop in both eyes on Day 29. Drug: AGN-210669 ophthalmic solution, 0.075% One drop of AGN-210669 ophthalmic solution, 0.075% in both eyes each evening from Day 1 through the evening prior to Day 29. Selected sites: One additional drop in both eyes on Day 29. Drug: AGN-210669 ophthalmic solution, 0.05% One drop of AGN-210669 ophthalmic solution, 0.05% in both eyes each evening from Day 1 through the evening prior to Day 29. Selected sites: One additional drop in both eyes on Day 29.

Route of Administration: Topical

In Vitro Use Guide

Simenepag (AGN-210676) is a selective prostaglandin EP2 agonist with EC50 of 5 nM. It is a less potent agonist for recombinant human prostaglandin receptors hEP3A and hDP with EC50s of 153 nM and 7749 nM, respectively.

Name

Type

Language

SIMENEPAG

Official Name

English

5-((((2R)-1-(4-((1S)-1-HYDROXYHEXYL)PHENYL)-5-OXOPYRROLIDIN-2-YL)METHOXY)METHYL) THIOPHENE-2-CARBOXYLIC ACID

Systematic Name

English

SIMENEPAG [USAN]

Common Name

English

Simenepag [WHO-DD]

Common Name

English

simenepag [INN]

Common Name

English

AGN210676

Code

English

2-THIOPHENECARBOXYLIC ACID,5-((((2R)-1-(4-((1S)-1-HYDROXYHEXYL)PHENYL)-5-OXO-2-PYRROLIDINYL)METHOXY)METHYL)-

Common Name

English

AGN-210676

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29705