Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H20N2O2S |
| Molecular Weight | 304.407 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCOC(=O)C1=CC2=C(NC3=C2CSCC3)C=C1
InChI
InChIKey=WNDHLINIYZAWCR-UHFFFAOYSA-N
InChI=1S/C16H20N2O2S/c1-18(2)6-7-20-16(19)11-3-4-14-12(9-11)13-10-21-8-5-15(13)17-14/h3-4,9,17H,5-8,10H2,1-2H3
Tipindole is serotonin antagonist. It is a monamine oxidase inhibitor. Diarrhea that arises in mice given serotonin intravenously is not suppressed by tipindole. Tipindole exerts no effect on the serotonin-induced contraction and relaxation of the bladder detrusor. Tipindole depresses reflexes from pericardial receptors considerably more than reflexes from carotid sinus receptors. Tipindole blocks chemoreceptors but has no effect on mechanoreceptors – it did not modify impulses produced by mechanoreceptors.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Pharmacologic analysis of the stimulating effect of serotonin on proliferation in cell cultures]. | 1978 Jun |
|
| Study on serotoninergic mechanisms of compensatory ovarian hypertrophy in rats. | 1980 Mar |
|
| [Pharmacologic analysis of the mechanism of development of serotonin diarrhea in the mouse]. | 1981 Jan-Feb |
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| [Effect of serotonin and its antagonists on bladder detrusor function]. | 1981 Nov-Dec |
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| [Effect of serotonin and its antagonists on the evoked responses of the dental zones of the rabbit cerebral cortex during stimulation of the dental pulp]. | 1981 Nov-Dec |
|
| [Serotonin independently stimulates fibroblast adhesion and multiplication in culture]. | 1982 Feb |
|
| [Changes in the properties of the monoamine receptors in the organs of tumor carriers]. | 1986 Jan-Feb |
| Name | Type | Language | ||
|---|---|---|---|---|
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Official Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C66885
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7489-66-9
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C76968
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2788
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DTXSID70225869
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US65H9WBNH
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100000077260
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SUB11104MIG
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CHEMBL494521
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C013716
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ACTIVE MOIETY
