Details
Stereochemistry | MIXED |
Molecular Formula | C20H25N3O3 |
Molecular Weight | 355.4308 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 0 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(O)C=CC(=C1)C(O)CNC(C)CCN2C=NC3=C2C=CC=C3
InChI
InChIKey=NKKPVWPMPWLEMY-UHFFFAOYSA-N
InChI=1S/C20H25N3O3/c1-14(9-10-23-13-22-16-5-3-4-6-17(16)23)21-12-19(25)15-7-8-18(24)20(11-15)26-2/h3-8,11,13-14,19,21,24-25H,9-10,12H2,1-2H3
Imoxiterol (also known as RP 58802B) is benzimidazole derivatives patented by pharmaceutical company Laboratoire Roger Bellon S. A as a long-acting β-adrenergic agonist. In preclinical models, nebulized Imoxiterol produced a rapid onset and long-lasting inhibition of histamine-induced bronchospasm in the anaesthetized guinea-pig. Given orally, Imoxiterol produced a greater than three-fold shift to the right of the dose-response curve and depressed the maximum response to histamine. Imoxiterol prevented the development of bronchial hyperreactivity. Although PAF-induced bronchial hyperreactivity was not accompanied by an increase in the number of pulmonary eosinophils, Imoxiterol reduced the numbers of eosinophils recovered by lavage. Imoxiterol significantly inhibited PAF-induced microvascular leakage into guinea-pigs lung.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1280178
oral guinea-pig: 5 mg/kg
Respiratory:
Route of Administration:
Oral
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C48149
Created by
admin on Fri Dec 15 16:09:00 GMT 2023 , Edited by admin on Fri Dec 15 16:09:00 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
CHEMBL2104918
Created by
admin on Fri Dec 15 16:09:00 GMT 2023 , Edited by admin on Fri Dec 15 16:09:00 GMT 2023
|
PRIMARY | |||
|
5647
Created by
admin on Fri Dec 15 16:09:00 GMT 2023 , Edited by admin on Fri Dec 15 16:09:00 GMT 2023
|
PRIMARY | |||
|
88578-07-8
Created by
admin on Fri Dec 15 16:09:00 GMT 2023 , Edited by admin on Fri Dec 15 16:09:00 GMT 2023
|
PRIMARY | |||
|
SUB08157MIG
Created by
admin on Fri Dec 15 16:09:00 GMT 2023 , Edited by admin on Fri Dec 15 16:09:00 GMT 2023
|
PRIMARY | |||
|
C83794
Created by
admin on Fri Dec 15 16:09:00 GMT 2023 , Edited by admin on Fri Dec 15 16:09:00 GMT 2023
|
PRIMARY | |||
|
100000083383
Created by
admin on Fri Dec 15 16:09:00 GMT 2023 , Edited by admin on Fri Dec 15 16:09:00 GMT 2023
|
PRIMARY | |||
|
65665
Created by
admin on Fri Dec 15 16:09:00 GMT 2023 , Edited by admin on Fri Dec 15 16:09:00 GMT 2023
|
PRIMARY | |||
|
UR4924C6G2
Created by
admin on Fri Dec 15 16:09:00 GMT 2023 , Edited by admin on Fri Dec 15 16:09:00 GMT 2023
|
PRIMARY |
ACTIVE MOIETY