Details
Stereochemistry | ACHIRAL |
Molecular Formula | C23H16O6.C13H16N2O |
Molecular Weight | 604.6485 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCCN=C1\C=C\C2=CC(O)=CC=C2.OC(=O)C3=CC4=C(C=CC=C4)C(CC5=C6C=CC=CC6=CC(C(O)=O)=C5O)=C3O
InChI
InChIKey=CCOAINFUFGBHBA-UETGHTDLSA-N
InChI=1S/C23H16O6.C13H16N2O/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-15-9-3-8-14-13(15)7-6-11-4-2-5-12(16)10-11/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2,4-7,10,16H,3,8-9H2,1H3/b;7-6+
DescriptionSources: http://shop.demas.it/admin/uploads/articoli/4582.pdfCurator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/7639515 | https://www.ncbi.nlm.nih.gov/pubmed/19506073 | http://parasitipedia.net/index.php?option=com_content&view=article&id=2504&Itemid=2777 | https://www.ncbi.nlm.nih.gov/pubmed/20038616
Sources: http://shop.demas.it/admin/uploads/articoli/4582.pdf
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/7639515 | https://www.ncbi.nlm.nih.gov/pubmed/19506073 | http://parasitipedia.net/index.php?option=com_content&view=article&id=2504&Itemid=2777 | https://www.ncbi.nlm.nih.gov/pubmed/20038616
Oxantel is a narrow-spectrum anthelmintic effective against whipworms in dogs and cats. It is ineffective against other roundworms, flukes, tapeworms or external parasites. Oxantel acts on the nervous system of the worms as inhibitors of acetylcholinesterase. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis. When oxantel was administrated to human beings for the treatment of trichuriasis, no drug reaction or side effects were reported, and the results of hematologic, biochemical and urinary examinations didn’t reveal any significant drug-related changes.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5059028
Curator's Comment: # Pfizer Inc.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL3341583 |
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Target ID: Fumarate reductase (Helicobacter pylori) |
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Target ID: CHEMBL2492 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19506073 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | TELOPAR Approved UseOxantel is a narrow-spectrum anthelmintic effective against whipworms in dogs and cats. |
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Curative | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: http://shop.demas.it/admin/uploads/articoli/4582.pdf
Dog: 140 mg. One tablet per 7 kg of body weight (20 mg of oxantel per 1 kg of body weight).
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7639515
The MIC, MBC and ICs values for Oxantel determined in laboratory-adapted strain NCTC 11639 of H. pylori. MIC=0.94 mM, MBC=0.94 mM, IC50=0.31 mM, IC90=1.04 mM. For the wild-type strain UNSW 10593/5 the MIC and MBC values were 0.47 nM.
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C250
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m8291
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272-332-6
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759296
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UPY1D732T0
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ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD