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Details

Stereochemistry RACEMIC
Molecular Formula C9H20N4.H2O.H2O4S
Molecular Weight 300.376
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GUANAZODINE SULFATE MONOHYDRATE

SMILES

O.OS(O)(=O)=O.NC(=N)NCC1CCCCCCN1

InChI

InChIKey=GJWAIVFCPHHUSD-UHFFFAOYSA-N
InChI=1S/C9H20N4.H2O4S.H2O/c10-9(11)13-7-8-5-3-1-2-4-6-12-8;1-5(2,3)4;/h8,12H,1-7H2,(H4,10,11,13);(H2,1,2,3,4);1H2

HIDE SMILES / InChI
Guanazodine is a new antihypertensive drug. Guanazodine caused a sustained decrease in the systemic blood pressure of spontaneously hypertensive rats, renal hypertensive dogs and normal cats. No tachyphylaxis developed when the drug was administered orally. The heart rate decreased. Guanazodine relaxed the cat nictitating membrane, attenuated the positive chronotropic response to sympathetic nerve stimulation in anesthetized dogs and in isolated rabbit aorta to transmural electrical stimulation. Guanazodine potentiated the pressor response to noradrenaline but attenuated the response to tyramine in anesthetized cats. It may be concluded that the hypotensive effect of guanazodine is related to adrenergic neuron blocking action, the noradrenaline-depleting action in peripheral tissues is similar to the effect of guanethidine and bethanidine. However, this drug is less potent than guanethidine. Toxicity and side effects appear to be less with guanazodine than with guanethidine and bethanidine.

Approval Year

Name Type Language
GUANAZODINE SULFATE MONOHYDRATE
MI  
Common Name English
1-AZACYCLOOCT-2-YLMETHYLGUANIDINE SULPHATE MONOHYDRATE
Systematic Name English
GUANAZODINE SULFATE [MART.]
Common Name English
((OCTAHYDRO-2-AZOCINYL)METHYL)GUANIDINE SULPHATE MONOHYDRATE
Systematic Name English
CALNEGYT
Brand Name English
GUANAZODINE SULFATE MONOHYDRATE [MI]
Common Name English
((OCTAHYDRO-2-AZOCINYL)METHYL)GUANIDINE SULFATE MONOHYDRATE
Systematic Name English
GUANAZODINE SULPHATE MONOHYDRATE
Common Name English
1-AZACYCLOOCT-2-YLMETHYLGUANIDINE SULFATE MONOHYDRATE
Systematic Name English
SANEGYT
Brand Name English
NSC-303851
Code English
.ALPHA.-GUANIDINOMETHYLHEPTAMETHYLENIMINE SULFATE MONOHYDRATE
Common Name English
EGYT-739
Code English
.ALPHA.-GUANIDINOMETHYLHEPTAMETHYLENIMINE SULPHATE MONOHYDRATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29709
Created by admin on Fri Dec 15 16:05:57 GMT 2023 , Edited by admin on Fri Dec 15 16:05:57 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C83742
Created by admin on Fri Dec 15 16:05:57 GMT 2023 , Edited by admin on Fri Dec 15 16:05:57 GMT 2023
PRIMARY
PUBCHEM
21124899
Created by admin on Fri Dec 15 16:05:57 GMT 2023 , Edited by admin on Fri Dec 15 16:05:57 GMT 2023
PRIMARY
NSC
303851
Created by admin on Fri Dec 15 16:05:57 GMT 2023 , Edited by admin on Fri Dec 15 16:05:57 GMT 2023
PRIMARY
FDA UNII
UKI3DAO4S6
Created by admin on Fri Dec 15 16:05:57 GMT 2023 , Edited by admin on Fri Dec 15 16:05:57 GMT 2023
PRIMARY
MERCK INDEX
m222
Created by admin on Fri Dec 15 16:05:57 GMT 2023 , Edited by admin on Fri Dec 15 16:05:57 GMT 2023
PRIMARY Merck Index