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Details

Stereochemistry ACHIRAL
Molecular Formula C13H16N2S2
Molecular Weight 264.41
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N-CYCLOHEXYL-2-BENZOTHIAZOSULFENAMIDE

SMILES

C1CCC(CC1)NSC2=NC3=C(S2)C=CC=C3

InChI

InChIKey=DEQZTKGFXNUBJL-UHFFFAOYSA-N
InChI=1S/C13H16N2S2/c1-2-6-10(7-3-1)15-17-13-14-11-8-4-5-9-12(11)16-13/h4-5,8-10,15H,1-3,6-7H2

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf

N-cyclohexyl-2-benzothiazosulfenamide (Sulfenax® CBS) is used in rubber industry in processing of natural and synthetic rubber in rubber compounds as a fast accelerator of vulcanization with delayed action. N-cyclohexyl-2-benzothiazosulfenamide is a chemical allergen. It is used for diagnosis of contact allergy. It is a component of Mercapto Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Approval Year

1994
155
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2637
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8307
T.R.U.E. TEST

Approved Use

T.R.U.E. TEST is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Launch Date

7.5712319E11
PubMed

PubMed

TitleDatePubMed
Development and application of an LC-MS method to determine possible migration of mercaptobenzothiazole, benzothiazole and related vulcanization residues from rubber used in contact with food and drink.
2003 Feb
Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts.
2011 Aug
Patents

Patents

JP2001279022A
1
JP2004204126A
1
JP2010536987A
4
JP4717814B2
1
JPH01138249A
1
JPH06256600A
1
JPH0693134A
1
JPH09194633A
2
JPH11172125A
1
JPS61233028A
1
JPS616644A
1
JPS616646A
1
JPS62169826A
1
JPS62241952A
1

Sample Use Guides

In Vivo Use Guide
Apply the three adhesive panels of allergens and allergen mixes on healthy skin of the back. Remove panels and evaluate the skin 48 hours after application. Re-evaluate the skin 72 to 96 hours after application.
Route of Administration: Topical
In Vitro Use Guide
10 uM of N-cyclohexyl-2-benzothiazosulfenamide induced AhR-dependent gene expression in mouse hepatoma (H1L6.1c2) cells
Name Type Language
N-CYCLOHEXYL-2-BENZOTHIAZOSULFENAMIDE
Common Name English
CBTS
Common Name English
SULFENAX
Brand Name English
2-(CYCLOHEXYLAMINOTHIO)BENZOTHIAZOLE [HSDB]
Common Name English
VULKACIT CZ
Brand Name English
THIOHEXAM
Common Name English
CBS
Common Name English
N-CYCLOHEXYLBENZOTHIAZYL-SULPHENAMIDE
Common Name English
2-BENZOTHIAZOLESULFENAMIDE, N-CYCLOHEXYL-
Systematic Name English
N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE
Systematic Name English
NSC-4809
Code English
Classification Tree Code System Code
NDF-RT N0000185508
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
Code System Code Type Description
EVMPD
SUB169427
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
EPA CompTox
DTXSID5020360
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
EVMPD
SUB61033
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
HSDB
2868
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
ECHA (EC/EINECS)
202-411-2
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
CAS
95-33-0
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
PUBCHEM
7232
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
MESH
C044169
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
DRUG BANK
DB14200
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY Increased Histamine Release [PE]
NDF-RT
N0000184306
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY Cell-mediated Immunity [PE]
RXCUI
1306886
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY RxNorm
FDA UNII
UCA53G94EV
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
DAILYMED
UCA53G94EV
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY Allergens [Chemical/Ingredient]
NSC
4809
Created by admin on Fri Dec 16 21:27:44 UTC 2022 , Edited by admin on Fri Dec 16 21:27:44 UTC 2022
PRIMARY
NIH
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