N-CYCLOHEXYL-2-BENZOTHIAZOSULFENAMIDE

US Approved Allergenic Extract (1994)

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H16N2S2
Molecular Weight	264.41
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of N-CYCLOHEXYL-2-BENZOTHIAZOSULFENAMIDE

Structure Search

SMILES

C1CCC(CC1)NSC2=NC3=C(S2)C=CC=C3

InChI

InChIKey=DEQZTKGFXNUBJL-UHFFFAOYSA-N

InChI=1S/C13H16N2S2/c1-2-6-10(7-3-1)15-17-13-14-11-8-4-5-9-12(11)16-13/h4-5,8-10,15H,1-3,6-7H2

HIDE SMILES / InChI

Description
Sources: https://www.duslo.sk/userfiles/products/en_sulfenax_cbs.pdf
Curator's Comment: Description was created based on several sources, including http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf

N-cyclohexyl-2-benzothiazosulfenamide (Sulfenax® CBS) is used in rubber industry in processing of natural and synthetic rubber in rubber compounds as a fast accelerator of vulcanization with delayed action. N-cyclohexyl-2-benzothiazosulfenamide is a chemical allergen. It is used for diagnosis of contact allergy. It is a component of Mercapto Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Aryl hydrocarbon receptor 27 Target ID: CHEMBL6099 Sources: http://www.ncbi.nlm.nih.gov/pubmed/21590714	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergic contact dermatitis 14 Sources: http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf	Diagnostic		Approved 8583	T.R.U.E. TEST Approved Use T.R.U.E. TEST is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels. Launch Date 1993

Doses

Dose	Population	Adverse events
1 % single, topical Studied dose Dose: 1 % Route: topical Route: single Dose: 1 % Sources: https://pubmed.ncbi.nlm.nih.gov/3233958/ https://pubmed.ncbi.nlm.nih.gov/5075717/	unhealthy, ADOLESCENT\|ADULT Health Status: unhealthy Age Group: ADOLESCENT\|ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/3233958/ https://pubmed.ncbi.nlm.nih.gov/5075717/	Other AEs: Contact dermatitis... Other AEs: Contact dermatitis (2.9%) Sources: https://pubmed.ncbi.nlm.nih.gov/3233958/ https://pubmed.ncbi.nlm.nih.gov/5075717/

AEs

AE	Significance	Dose	Population
Contact dermatitis	2.9%	1 % single, topical Studied dose Dose: 1 % Route: topical Route: single Dose: 1 % Sources: https://pubmed.ncbi.nlm.nih.gov/3233958/ https://pubmed.ncbi.nlm.nih.gov/5075717/	unhealthy, ADOLESCENT\|ADULT Health Status: unhealthy Age Group: ADOLESCENT\|ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/3233958/ https://pubmed.ncbi.nlm.nih.gov/5075717/

PubMed

Title	Date	PubMed
Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts.	2011-08	21590714
Development and application of an LC-MS method to determine possible migration of mercaptobenzothiazole, benzothiazole and related vulcanization residues from rubber used in contact with food and drink.	2003-02	12623669

Patents

Sample Use Guides

In Vivo Use Guide

Apply the three adhesive panels of allergens and allergen mixes on healthy skin of the back. Remove panels and evaluate the skin 48 hours after application. Re-evaluate the skin 72 to 96 hours after application.

Route of Administration: Topical

In Vitro Use Guide

10 uM of N-cyclohexyl-2-benzothiazosulfenamide induced AhR-dependent gene expression in mouse hepatoma (H1L6.1c2) cells

Name

Type

Language

SULFENAX

Preferred Name

English

N-CYCLOHEXYL-2-BENZOTHIAZOSULFENAMIDE

Common Name

English

CBTS

Common Name

English

2-(CYCLOHEXYLAMINOTHIO)BENZOTHIAZOLE [HSDB]

Common Name

English

VULKACIT CZ

Brand Name

English

THIOHEXAM

Common Name

English

CBS

Common Name

English

N-CYCLOHEXYLBENZOTHIAZYL-SULPHENAMIDE

Common Name

English

2-BENZOTHIAZOLESULFENAMIDE, N-CYCLOHEXYL-

Systematic Name

English

N-CYCLOHEXYL-2-BENZOTHIAZOLESULFENAMIDE

Systematic Name

English

NSC-4809

Code

English

Classification Tree Code System Code

NDF-RT

N0000185508