Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C13H14N2O3 |
Molecular Weight | 246.2619 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O
InChI
InChIKey=DZTHIGRZJZPRDV-LBPRGKRZSA-N
InChI=1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1
Acetyltryptophan, L- functions readily as a component of the food in place of the free amino acid. Acetyltryptophan, L- is a neurokinin-1 receptor antagonist. It significantly improved motor and cognitive outcomes in models of Parkinson’s diseases, as well as reduced brain edema and axonal injury in experimental traumatic brain injury and stroke. It is a potent therapeutic agent for the treatment of amyotrophic lateral sclerosis.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL249 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26031348 |
|||
Target ID: WP254 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26031348 |
|||
Target ID: CHEMBL3314 Sources: https://www.ncbi.nlm.nih.gov/pubmed/518837 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease. | 2012 |
|
N-acetyl-L-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model. | 2015 Aug |
|
N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis. | 2015 Sep |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22485158
Rat: 2 uL of 50 nM
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26031348
Incubation with Acetyltryptophan,L- resulted in statistically significant inhibition of H2O2-mediated NSC-34 motoneuron cell death. The resulting curve (plotted semi-logarithmically) define the IC50 and maximum protection afforded by acetyltryptophan, L- (0.3 uM and 47%, respectively).
Name | Type | Language | ||
---|---|---|---|---|
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
90726
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
1218-34-4
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
700653
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
74640
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
214-935-9
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
DTXSID10883669
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
SUB28834
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
1700523
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
100000092546
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
U9264T8OAE
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
1366817
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
143877
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY | |||
|
133746
Created by
admin on Fri Dec 15 18:46:13 GMT 2023 , Edited by admin on Fri Dec 15 18:46:13 GMT 2023
|
PRIMARY |
SALT/SOLVATE (PARENT)
SUBSTANCE RECORD