The usual intravenous dose is 1.5 to 5.0 mL per varix. The maximum dose per treatment session should not exceed 20 mL. Patients with significant liver dysfunction (Child Class C) or concomitant cardiopulmonary disease should usually receive less than the recommended maximum dose.

The effect of ethanolamine oleate (EO) and its constituents on blood coagulation was studied by means of recalcification clotting time (RCT) and FPA formation. RCT was performed using either fresh citrated whole blood or pooled plasma as substrates. The clotting end point of whole blood RCT and plasma RCT was recorded by the manual hook method and automated Clotek system, respectively. For determination of FPA formed in vitro, 250 pl fresh citrated blood was incubated with 50 ul EO or its constituent in a siliconized glass tube at 37°C for 1 min and the reaction was started by addition of 100 uL 15 mM CaCI2. At designated times, the reaction was terminated by addition of 100 uL 100 mM EDTA and 500 uL of chilled ethanol. And the supernatant of the mixture was subjected to the radioimmunoassay.