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Details

Stereochemistry ACHIRAL
Molecular Formula C18H18ClNOS
Molecular Weight 331.86
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZOTEPINE

SMILES

CN(C)CCOC1=CC2=C(SC3=CC=C(Cl)C=C13)C=CC=C2

InChI

InChIKey=HDOZVRUNCMBHFH-UHFFFAOYSA-N
InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3

HIDE SMILES / InChI

Description

Zotepine is a potent antipsychotic and antidepressive drug, which was developed in Japan and used in many countries for the treatment of schizophrenia. Zotepine has high affinity to D2, 5-HT2A, 5-HT2C, 5-HT6, 5-HT7, alpha1A, H1, and D1 receptors at therapeutically relevant concentrations and has similar affinities to 5-HT1A, alpha2A, and M1 receptors at high concentrations. In human zotepine is metabolized to a major metabolite, norzotepine, which has profile similar to that of zotepine for important neurotransmitter receptors known to be responsible for zotepine antipsychotic activity.The drug is still available in Asia.

CNS Activity

Approval Year

PubMed

PubMed

TitleDatePubMed
Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study.
2009 Dec
Application of on-line electrochemistry/electrospray/tandem mass spectrometry to a quantification method for the antipsychotic drug zotepine in human serum.
2009 Oct
Ziprasidone versus other atypical antipsychotics for schizophrenia.
2009 Oct 7
First-generation vs second-generation antipsychotic drugs: The ongoing saga.
2010 Jan
Zotepine versus other atypical antipsychotics for schizophrenia.
2010 Jan 20
Quetiapine versus other atypical antipsychotics for schizophrenia.
2010 Jan 20
Amisulpride versus other atypical antipsychotics for schizophrenia.
2010 Jan 20
Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia.
2010 Mar
QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia.
2010 Mar 17
Prolonged withdrawal delirium in concomitant diphenhydramine and nefopam dependence: A case report.
2010 May 30
Patents

Patents

Sample Use Guides

In Vivo Use Guide
The usual adult dosage for oral use is 75 mg to 150 mg of zotepine daily in divided doses.
Route of Administration: Oral
Name Type Language
ZOTEPINE
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
ZOTEPIN
Common Name English
ZOTEPINE [MART.]
Common Name English
NIPOLEPT
Brand Name English
2-((8-CHLORODIBENZO(B,F)THIEPIN-10-YL)OXY)-N,N-DIMETHYLETHYLAMINE
Systematic Name English
ZOTEPINE [MI]
Common Name English
SETOUS
Brand Name English
ZOTEPINE [INN]
Common Name English
ZOTEPINE [WHO-DD]
Common Name English
ZOTEPINE [JAN]
Common Name English
Classification Tree Code System Code
WHO-VATC QN05AX11
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
WHO-ATC N05AX11
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
Code System Code Type Description
INN
4112
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY
NCI_THESAURUS
C81096
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY
EVMPD
SUB00191MIG
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY
ChEMBL
CHEMBL285802
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY
CAS
26615-21-4
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY
MESH
C022172
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY
DRUG BANK
DB09225
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY
WIKIPEDIA
ZOTEPINE
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY
MERCK INDEX
M11667
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY Merck Index
EPA CompTox
26615-21-4
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY
PUBCHEM
5736
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY SWITZERF
RXCUI
40003
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY RxNorm
IUPHAR
103
Created by admin on Tue Mar 06 12:32:49 UTC 2018 , Edited by admin on Tue Mar 06 12:32:49 UTC 2018
PRIMARY