U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C15H18O7
Molecular Weight 310.2992
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PICROTIN

SMILES

[H][C@@]12OC(=O)[C@@]34O[C@@H]3C[C@@](O)([C@@H]5[C@@H]([C@H]1OC5=O)C(C)(C)O)[C@@]24C

InChI

InChIKey=RYEFFICCPKWYML-QCGISDTRSA-N
InChI=1S/C15H18O7/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9/h5-9,18-19H,4H2,1-3H3/t5-,6+,7-,8-,9-,13-,14-,15+/m1/s1

HIDE SMILES / InChI

Description

Picrotin is a component of picrotoxin, an equimolar mixture of picrotoxinin and picrotin, which was isolated from the fruit of Anamirta cocculus. Picrotin is inactive in inhibiting the GABA-A and GABA-C receptors, but the compound is able to block homomeric alpha1 and alpha1 beta glycine receptors. Picrotoxin is used as an antidote to severe barbiturate poisoning, however picrotin does not participate in the activity. Picrotin is not toxic.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
5.2 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown