Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H40O3 |
| Molecular Weight | 412.6047 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 3 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)\C=C\[C@H](O)C4CC4
InChI
InChIKey=LWQQLNNNIPYSNX-CIJZWTHJSA-N
InChI=1S/C27H40O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3/b13-6+,19-7+,21-10-/t17-,22-,23-,24+,25+,26+,27-/m1/s1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.medchemexpress.com/24R-Calcipotriol.html
Curator's Comment: description was created based on several sources, including
https://www.medchemexpress.com/24R-Calcipotriol.html
24R-Calcipotriol (PRI 2202) is an impurity of Calcipotriol. 24R-Calcipotriol shows the strong antiproliferative activity on the human breast cancer cell line MCF-7
Originator
Approval Year
Sample Use Guides
Mammary gland cancer 4T1-bearing mice were treated by 24R-Calcipotriol alone and 24R-Calcipotriol with cytostatic (cyclophosphamide). Cytostatic was administered i.p., dose 20 mg/kg on days 2, 5, 7, 9, 12, 14, 16, 19 and 21; 3vitamin D analogs were administered s.c., dose 10 Мg/kg on the same days as Cytostatic
Route of Administration:
Transdermal
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112827-99-3
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SUBSTANCE RECORD
