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Details

Stereochemistry ACHIRAL
Molecular Formula C10H17N9O2S3
Molecular Weight 391.496
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TUVATIDINE

SMILES

CN1C(N)=NS(=O)(=O)N=C1NCCSCC2=CSC(NC(N)=N)=N2

InChI

InChIKey=FSWCCDQGXZITPD-UHFFFAOYSA-N
InChI=1S/C10H17N9O2S3/c1-19-8(13)17-24(20,21)18-9(19)14-2-3-22-4-6-5-23-10(15-6)16-7(11)12/h5H,2-4H2,1H3,(H2,13,17)(H,14,18)(H4,11,12,15,16)

HIDE SMILES / InChI
Tuvatidine (HUK 978) is a potent H2-antagonist. HUK 978 was shown to be devoid of activity at the histamine H1-receptor, the muscarinic receptor and the alpha and beta-adrenergic receptors. In both the guinea-pig gastric mucosa preparation and the rat perfused stomach model, HUK 978 was a powerful inhibitor of acid secretion. HUK 978 is a highly specific H2-antagonist and inhibits acid secretion for longer periods than other competitive compounds.

Approval Year

PubMed

PubMed

TitleDatePubMed
Anti-secretory activity of the novel H2-antagonist, HUK 978, in rat, guinea-pig and dog.
1985 Nov 4
In vitro histamine H2-antagonist activity of the novel compound HUK 978.
1985 Nov 4

Sample Use Guides

Dogs: The effect of the continuous intravenous infusion of different doses of HUK 978 (0.02 to 0.06 uM/kg/h). At doses close to the ID50 values, HUK 978 (0.07 uM/kg) gave almost twice the inhibition at 120 min post dose compared to cimetidine.
Route of Administration: Intragastric
In Vitro Use Guide
Tuvatidine (HUK 978) inhibited histamine stimulated adenylate cyclase from guinea-pig gastric fundic mucosa in a dose dependent manner. HUK 978 had no effect on the unstimulated basal activity of adenylate cyclase. Analysis by the method of Schild from six separate experiments gave a mean KB value of 4.8 x 10(-8) M with a slope of 1.03 showing the antagonism to be competitive. Using membranes prepared from guinea-pig cerebral cortex, HUK 978 inhibited 3H-tiotidine binding with a Ki of 2.0 x 10(-8) M.
Name Type Language
TUVATIDINE
INN  
INN  
Official Name English
tuvatidine [INN]
Common Name English
(4-(((2-((5-AMINO-4-METHYL-4H-1,24,6-THRIATRIAZIN-3-YL)AMINO)ETHYL)THIO)METHYL)-2-THIAZOLYL)GUANIDINE S'',S''-DIOXIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29702
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
Code System Code Type Description
FDA UNII
TWN203TLYT
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
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PUBCHEM
135481901
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
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CAS
91257-14-6
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
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NCI_THESAURUS
C73216
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
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EPA CompTox
DTXSID80238465
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
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EVMPD
SUB11368MIG
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
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ChEMBL
CHEMBL1742458
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
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INN
5799
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
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SMS_ID
100000076655
Created by admin on Fri Dec 15 16:29:03 GMT 2023 , Edited by admin on Fri Dec 15 16:29:03 GMT 2023
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