U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

PubMed

PubMed

TitleDatePubMed
The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.
2001 Apr
[Leu-enkephalin homogeneously labeled with tritium in studying the Selank inhibiting effect on the enkephalin-degrading enzymes of human plasma].
2004 May-Jun
[Effects of the new peptide anxiolytic drug selank on the cardiovascular system functioning and respiration in cats].
2005 Jul-Aug
[Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application].
2006 Mar-Apr
[Selank-induced normalizing effects on the integrative brain activity and biogenic amine level disorders due to antenatal hypoxia].
2006 Nov
[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].
2008
Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo.
2008 Jul-Aug
[Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice].
2008 Mar-Apr
[Compensatory and antiamnestic effects of heptapeptide Selank in monkeys].
2008 May-Jun
[Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study].
2008 Sep-Oct
[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA].
2009 Jul-Aug
Transcriptomic response of rat hippocampus and spleen cells to single and chronic administration of the peptide selank.
2010 Jan-Feb
Name Type Language
SELANK
Common Name English
TP 7
Common Name English
L-PROLINE, 1-(N-(1-(N2-(1-(N2-L-THREONYL-L-LYSYL)-L-PROLYL)-L-ARGINYL)-L-PROLYL)GLYCYL)-
Systematic Name English
SELANC
Common Name English
L-PROLINE, L-THREONYL-L-LYSYL-L-PROLYL-L-ARGINYL-L-PROLYLGLYCYL-
Systematic Name English
THR-LYS-PRO-ARG-PRO-GLY-PRO
Systematic Name English
THREONYL-LYSYL-PROLYL-ARGINYL-PROLYL-GLYCYL-PROLINE
Systematic Name English
Code System Code Type Description
WIKIPEDIA
SELANK
Created by admin on Sat Dec 16 15:39:59 GMT 2023 , Edited by admin on Sat Dec 16 15:39:59 GMT 2023
PRIMARY Selank is a synthetic analogue of the immunomodulatory peptide tuftsinas such, it mimics many of its effects. It has been shown to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines. It has been shown to influence the concentration of monoamine neurotransmitters and induce metabolism of serotonin. Selank has also been found to rapidly elevate the expression of brain-derived neurotropic factor (BDNF) in the hippocampus of rats.
DAILYMED
TS9JR8EP1G
Created by admin on Sat Dec 16 15:39:59 GMT 2023 , Edited by admin on Sat Dec 16 15:39:59 GMT 2023
PRIMARY
CAS
129954-34-3
Created by admin on Sat Dec 16 15:39:59 GMT 2023 , Edited by admin on Sat Dec 16 15:39:59 GMT 2023
PRIMARY
MANUFACTURER PRODUCT INFORMATION
SELANK
Created by admin on Sat Dec 16 15:39:59 GMT 2023 , Edited by admin on Sat Dec 16 15:39:59 GMT 2023
PRIMARY
FDA UNII
TS9JR8EP1G
Created by admin on Sat Dec 16 15:39:59 GMT 2023 , Edited by admin on Sat Dec 16 15:39:59 GMT 2023
PRIMARY
RXCUI
2049928
Created by admin on Sat Dec 16 15:39:59 GMT 2023 , Edited by admin on Sat Dec 16 15:39:59 GMT 2023
PRIMARY
PUBCHEM
11765600
Created by admin on Sat Dec 16 15:39:59 GMT 2023 , Edited by admin on Sat Dec 16 15:39:59 GMT 2023
PRIMARY
EPA CompTox
DTXSID701029276
Created by admin on Sat Dec 16 15:39:59 GMT 2023 , Edited by admin on Sat Dec 16 15:39:59 GMT 2023
PRIMARY