U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry EPIMERIC
Molecular Formula C35H64FN2O8PS
Molecular Weight 722.928
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FOSALVUDINE TIDOXIL

SMILES

CCCCCCCCCCCCSCC(COP(O)(=O)OC[C@H]1O[C@H](C[C@@H]1F)N2C=C(C)C(=O)NC2=O)OCCCCCCCCCC

InChI

InChIKey=JHXLLEDIXXOJQD-WELGVCPWSA-N
InChI=1S/C35H64FN2O8PS/c1-4-6-8-10-12-14-15-17-19-21-23-48-28-30(43-22-20-18-16-13-11-9-7-5-2)26-44-47(41,42)45-27-32-31(36)24-33(46-32)38-25-29(3)34(39)37-35(38)40/h25,30-33H,4-24,26-28H2,1-3H3,(H,41,42)(H,37,39,40)/t30?,31-,32+,33+/m0/s1

HIDE SMILES / InChI
Heidelberg Pharma Research developed fosalvudine tidoxil, a prodrug derived from the nucleoside reverse transcriptase inhibitor alovudine, for the treatment of HIV infections. This drug had reached phase II clinical trials before its development was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrug.
2009 Jul
Name Type Language
FOSALVUDINE TIDOXIL
INN  
INN  
Official Name English
fosalvudine tidoxil [INN]
Common Name English
5'-THYMIDYLIC ACID, 3'-DEOXY-3'-FLUORO-, MONO(2-(DECYLOXY)-3-(DODECYLTHIO)PROPYL) ESTER
Common Name English
(2RS)-2-(DECYLOXY)-3-((DODECYL)SULFANYL)PROPYL ((2R,3S,5R)-3-FLUORO-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-YL)METHYL HYDROGEN PHOSPHATE
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID10227221
Created by admin on Sat Dec 16 05:40:37 GMT 2023 , Edited by admin on Sat Dec 16 05:40:37 GMT 2023
PRIMARY
SMS_ID
300000036932
Created by admin on Sat Dec 16 05:40:37 GMT 2023 , Edited by admin on Sat Dec 16 05:40:37 GMT 2023
PRIMARY
INN
8677
Created by admin on Sat Dec 16 05:40:37 GMT 2023 , Edited by admin on Sat Dec 16 05:40:37 GMT 2023
PRIMARY
FDA UNII
TR856337M2
Created by admin on Sat Dec 16 05:40:37 GMT 2023 , Edited by admin on Sat Dec 16 05:40:37 GMT 2023
PRIMARY
CAS
763903-67-9
Created by admin on Sat Dec 16 05:40:37 GMT 2023 , Edited by admin on Sat Dec 16 05:40:37 GMT 2023
PRIMARY
PUBCHEM
11563925
Created by admin on Sat Dec 16 05:40:37 GMT 2023 , Edited by admin on Sat Dec 16 05:40:37 GMT 2023
PRIMARY
NCI_THESAURUS
C170005
Created by admin on Sat Dec 16 05:40:37 GMT 2023 , Edited by admin on Sat Dec 16 05:40:37 GMT 2023
PRIMARY