MEPIPRAZOLE DIHYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H21ClN4.2ClH
Molecular Weight	377.74
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MEPIPRAZOLE DIHYDROCHLORIDE

Structure Search

SMILES

Cl.Cl.CC1=CC(CCN2CCN(CC2)C3=CC=CC(Cl)=C3)=NN1

InChI

InChIKey=FOZDCFRVHJVSIY-UHFFFAOYSA-N

InChI=1S/C16H21ClN4.2ClH/c1-13-11-15(19-18-13)5-6-20-7-9-21(10-8-20)16-4-2-3-14(17)12-16;;/h2-4,11-12H,5-10H2,1H3,(H,18,19);2*1H

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/989382 | https://www.ncbi.nlm.nih.gov/pubmed/9660 | https://www.ncbi.nlm.nih.gov/pubmed/7255266 | https://www.ncbi.nlm.nih.gov/pubmed/1095510 | https://www.ncbi.nlm.nih.gov/pubmed/769484

Mepiprazole is a psychotropic pyrazole derivative. Mepiprazole is a serotonin reuptake inhibitor and adrenolytic. In clinical studies, it demonstrated anxiolytic properties.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
[A controlled double-blind crossover study of the efficacy of mepiprazol (EMD 16.923) and of diazepam in the treatment of neurotic disorders].	1975 May	769484
[Psychopharmological research with EMD 16-923 in patients with different degrees of anxiety].	1976	1052713
Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes.	1976 Aug 17	9660
The effect of mepiprazole on central monoamine neurons. Evidence for increased 5-hydroxytryptamine and dopamine receptor activity.	1976 Jan	943291
Central action of mepiprazole.	1980 Jul-Aug	7255266
Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats.	1983 Sep-Oct	6311738

Patents

Name

Type

Language

MEPIPRAZOLE DIHYDROCHLORIDE

Common Name

English

H 4007

Code

English

1-(3-CHLOROPHENYL)-4-(2-(5-METHYL-1H-PYRAZOL-3-YL)ETHYL)PIPERAZINE DIHYDROCHLORIDE

Systematic Name

English

PIPERAZINE, 1-(3-CHLOROPHENYL)-4-(2-(5-METHYL-1H-PYRAZOL-3-YL)ETHYL)-, HYDROCHLORIDE (1:2)

Systematic Name

English

MEPIPRAZOLE DIHYDROCHLORIDE [MI]

Common Name

English

PSIGODAL

Brand Name

English

QUIADON

Brand Name

English

H-4007

Code

English

Code System Code Type Description

EPA CompTox

DTXSID80942499