U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H5NO2
Molecular Weight 75.0667
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYCINE

SMILES

C(C(=O)O)N

InChI

InChIKey=DHMQDGOQFOQNFH-UHFFFAOYSA-N
InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

HIDE SMILES / InChI
Glycine (Cly) is a natural amino acid neurotransmitter that acts as a co-agonist at Glutamate [NMDA] receptors in the brain and is an activator of glycine receptors, GLRA1-3, GLRB. The abnormal Gly levels have been implicated in neuropsychiatric disorders. Alterations in Gly levels are implicated in several diseases of the central nervous system. Glycine was studied in phase II of clinical trials in patients with schizophrenia. The results have shown that using of glycine was associated with reduced symptoms with promising effect sizes and a possibility of improvement in cognitive function. Besides, glycine was also studied in clinical trials phase II in children with cystic fibrosis. The clinical, spirometric and inflammatory status of subjects with cystic fibrosis improved after just 8 weeks of glycine intake, suggesting that this amino acid might constitute a novel therapeutic tool for these patients. In addition, Gly was proposed as a biomarker for brain tumor malignancy. Glycine is a component of a nutrients mixture for peripheral administration to well-nourished mildly catabolic adult patients who require only short-term parenteral nutrition.

CNS Activity

Curator's Comment:: Known to be CNS non-penetrant in rabbit. Human data not available.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Preventing
FREAMINE III 8.5%

Approved Use

Aminosyn, Sulfite-Free, (a crystalline amino acid solution) infused with dextrose by peripheral vein infusion is indicated as a source of nitrogen in the nutritional support of patients with adequate stores of body fat, in whom, for short periods of time, oral nutrition cannot be tolerated, is undesirable, or inadequate. SUPPLEMENTAL ELECTROLYTES, IN ACCORDANCE WITH THE PRESCRIPTION OF THE ATTENDING PHYSICIAN, MUST BE ADDED TO AMINOSYN SOLUTIONS WITHOUT ELECTROLYTES. Aminosyn can be administered peripherally with dilute (5 to 10%) dextrose solution and I.V. fat emulsion as a source of nutritional support. This form of nutritional support can help to preserve protein and reduce catabolism in stress conditions where oral intake is inadequate. When administered with concentrated dextrose solutions with or without fat emulsions, Aminosyn is also indicated for central vein infusion to prevent or reverse negative nitrogen balance in patients where: (a) the alimentary tract, by the oral, gastrostomy or jejunostomy route cannot or should not be used; (b) gastrointestinal absorption of protein is impaired; (c) metabolic requirements for protein are substantially increased as with extensive burns and (d) morbidity and mortality may be reduced by replacing amino acids lost from tissue breakdown, thereby preserving tissue reserves, as in acute renal failure.

Launch Date

5.4431998E10
PubMed

PubMed

TitleDatePubMed
Sustained L-type calcium currents in dissociated deep dorsal horn neurons of the rat: characteristics and modulation.
2001
Identification of genetic variants (g789C>T and G111S) in the human HSPB2 gene.
2001
Identification of the first reported splice site mutation (IVS7-1G-->A) in the aminomethyltransferase (T-protein) gene (AMT) of the glycine cleavage complex in 3 unrelated families with nonketotic hyperglycinemia.
2001
Pharmacological profiles of the metabotropic glutamate receptor ligands.
2001
Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.
2001 Apr 13
Functional conservation of phosphorylation-specific prolyl isomerases in plants.
2001 Apr 27
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
2001 Apr 6
Distribution of transcripts for the brain-specific GDP/GTP exchange factor collybistin in the developing mouse brain.
2001 Feb
Atypical neural messengers.
2001 Feb
High-affinity zinc potentiation of inhibitory postsynaptic glycinergic currents in the zebrafish hindbrain.
2001 Feb
Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1.
2001 Feb
Amino acid interconversions in the fetal-placental unit: the animal model and human studies in vivo.
2001 Feb
A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13.
2001 Feb
Hamster sperm glycine receptor: evidence for its presence and involvement in the acrosome reaction.
2001 Feb
Trimethylamine oxide counteracts effects of hydrostatic pressure on proteins of deep-sea teleosts.
2001 Feb 15
Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes.
2001 Feb 15
Evidence for microvesicular storage and release of glycine in rodent pinealocytes.
2001 Feb 16
Ligand-independent dimerization and activation of the oncogenic Xmrk receptor by two mutations in the extracellular domain.
2001 Feb 2
Amino acid residues outside of the pore region contribute to N-type calcium channel permeation.
2001 Feb 23
Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
2001 Feb 6
An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease.
2001 Jan
Generalized dystrophic epidermolysis bullosa: identification of a novel, homozygous glycine substitution, G2031S, in exon 73 of COL7A1 in monozygous triplets.
2001 Jan
Determination of bile acids in biological fluids by liquid chromatography-electrospray tandem mass spectrometry.
2001 Jan
cAMP-dependent presynaptic regulation of spontaneous glycinergic IPSCs in mechanically dissociated rat spinal cord neurons.
2001 Jan
Slow dorsal-ventral rhythm generator in the lamprey spinal cord.
2001 Jan
Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse.
2001 Jan
Microdialysis study of amino acid neurotransmitters in the spinal dorsal horn of patients undergoing microsurgical dorsal root entry zone lesioning. Technical note.
2001 Jan
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition.
2001 Jan
Disorders of membrane channels or channelopathies.
2001 Jan
Use of trifluoroperazine isolates a [(3)H]Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits.
2001 Jan
Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area.
2001 Jan
Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma.
2001 Jan
In vitro studies of a prolactin antagonist, hPRL-G129R in human breast cancer cells.
2001 Jan
A high resolution (1)H magic angle spinning NMR study of a high-M(r) subunit of wheat glutenin.
2001 Jan
Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P, and preproenkephalin mRNA expression in rat dorsal striatum.
2001 Jan
Analysis of glycoconjugate patterns of normal and hormone-induced dysplastic Noble rat prostates, and an androgen-independent Noble rat prostate tumor, by lectin histochemistry and protein blotting.
2001 Jan 1
Regulation of a mammalian Shaker-related potassium channel, hKv1.5, by extracellular potassium and pH.
2001 Jan 12
Mechanism of action of a novel latent membrane protein-1 dominant negative.
2001 Jan 12
Intensity-dependent, rapid activation of presynaptic metabotropic glutamate receptors at a central synapse.
2001 Jan 15
Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor.
2001 Jan 15
Familial Tetralogy of Fallot caused by mutation in the jagged1 gene.
2001 Jan 15
Intracellular folding pathway of the cystine knot-containing glycoprotein hormone alpha-subunit.
2001 Jan 16
Chemical rescue of phosphoryl transfer in a cavity mutant: a cautionary tale for site-directed mutagenesis.
2001 Jan 16
Ultrastructural evidence for direct projections from the pontine micturition center to glycine-immunoreactive neurons in the sacral dorsal gray commissure in the cat.
2001 Jan 22
Engineering conformational flexibility in the lactose permease of Escherichia coli: use of glycine-scanning mutagenesis to rescue mutant Glu325-->Asp.
2001 Jan 23
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
2001 Jan 5
Differential roles of two conserved glycine residues in the fusion peptide of Semliki Forest virus.
2001 Jan 5
Functional reconstitution and characterization of recombinant human alpha 1-glycine receptors.
2001 Jun 15
Glycine reduces novelty- and methamphetamine-induced locomotor activity in neonatal ventral hippocampal damaged rats.
2001 Mar
(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
2001 Mar
Patents

Sample Use Guides

Daily oral supplement of glycine at a dose of 0.5 g/kg divided in three doses during 8 weeks
Route of Administration: Oral
The excess of glycine inhibits the growth of many bacteria, and it is used as a nonspecific antiseptic agent due to its low level of toxicity in animals. The MIC at which 90% of strains are inhibited for glycine was almost 2.5 mg/ml for 31 strains of H. pylori, including CLR-resistant strains.
Name Type Language
GLYCINE
EP   FCC   FHFI   GREEN BOOK   HSDB   II   INCI   INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INCI   INN  
Official Name English
SERINE IMPURITY B [EP]
Common Name English
GLYCINE [INCI]
Common Name English
GLYCINE [VANDF]
Common Name English
FEMA NO. 3287
Code English
GLYCINE [MART.]
Common Name English
GLYCOLIXIR
Brand Name English
GLYCINE [ORANGE BOOK]
Common Name English
GLYCINE [HSDB]
Common Name English
GLYCINE [FHFI]
Common Name English
GLYCINE [WHO-DD]
Common Name English
GLYCINE [GREEN BOOK]
Common Name English
AMINOACETIC ACID
Systematic Name English
GLYCINE [USP]
Common Name English
GLYCINE [FCC]
Common Name English
GLYCINE [II]
Common Name English
AMINOETHANOIC ACID
Systematic Name English
GLYCINE [USP-RS]
Common Name English
GLYCOCOLL
Common Name English
NSC-25936
Code English
GLYCINE [EP MONOGRAPH]
Common Name English
GLYCINE [MI]
Common Name English
2-AMINOACETIC ACID
Systematic Name English
GLYCINE [INN]
Common Name English
Classification Tree Code System Code
LOINC 25922-6
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
CFR 21 CFR 520.1060
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LOINC 2389-5
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LOINC 2390-3
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JECFA EVALUATION GLYCINE
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LOINC 13750-5
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CFR 21 CFR 172.320
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LOINC 47635-8
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LOINC 56681-0
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WHO-ATC B05CX03
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LOINC 47636-6
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LOINC 15135-7
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LOINC 2392-9
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LOINC 47639-0
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CFR 21 CFR 170.50
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LOINC 22650-6
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LOINC 20644-1
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LOINC 47638-2
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LOINC 44365-5
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LOINC 13397-5
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LOINC 30066-5
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LOINC 47634-1
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LOINC 26929-0
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LOINC 26807-8
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LOINC 27325-0
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LOINC 32245-3
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LOINC 47637-4
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LOINC 25921-8
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CFR 21 CFR 310.532
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CFR 21 CFR 582.5049
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LOINC 47633-3
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LOINC 55862-7
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CFR 21 CFR 331.11
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LOINC 22709-0
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DSLD 177 (Number of products:5)
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LOINC 15143-1
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LOINC 2391-1
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LOINC 2393-7
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DSLD 92 (Number of products:1270)
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LOINC 22718-1
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CFR 21 CFR 331.15
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WHO-VATC QB05CX03
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
CFR 21 CFR 172.812
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
Code System Code Type Description
FDA UNII
TE7660XO1C
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
EVMPD
SUB12000MIG
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
WIKIPEDIA
GLYCINE
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
INN
630
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
MESH
D005998
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
NCI_THESAURUS
C524
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
PUBCHEM
750
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
HSDB
495
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
EPA CompTox
56-40-6
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
ChEMBL
CHEMBL773
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
CAS
56-40-6
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
MERCK INDEX
M5796
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY Merck Index
DRUG BANK
DB00145
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
RXCUI
4919
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY RxNorm
DRUG CENTRAL
1319
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-272-2
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY
USP_CATALOG
1295800
Created by admin on Fri Jun 25 21:11:28 UTC 2021 , Edited by admin on Fri Jun 25 21:11:28 UTC 2021
PRIMARY USP-RS