Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C29H32F3N5O6S |
| Molecular Weight | 635.654 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC(=CC(C)=C1CCS(=O)(=O)N2CCC3(CC2)N=C(NC3=O)C4=CC=C(OC(F)(F)F)C=C4)N5C(=O)NC(=O)C5(C)C
InChI
InChIKey=LDZJFVOUPUFOHX-UHFFFAOYSA-N
InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44(41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30,31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)
Chugai Pharmaceutical is developing a parathyroid 1 receptor agonist called as PCO371. It is known that parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor. PCO371 can provide a new treatment option for PTH-related disorders, including hypoparathyroidism. This drug participated in phase I clinical trial in healthy volunteers. However, Chugai Pharmaceutical has terminated this study. No recent reports of the development of PCO371are available.
Approval Year
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FDA ORPHAN DRUG |
455914
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1613373-33-3
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DB14946
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TE53TU0WSQ
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76283707
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ACTIVE MOIETY
