Details
Stereochemistry | RACEMIC |
Molecular Formula | C15H18O5 |
Molecular Weight | 278.3004 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)OC1=C(C)C2=C(OC(CC(O)=O)C2)C(C)=C1C
InChI
InChIKey=QLWBKUUORSULMI-UHFFFAOYSA-N
InChI=1S/C15H18O5/c1-7-8(2)15-12(5-11(20-15)6-13(17)18)9(3)14(7)19-10(4)16/h11H,5-6H2,1-4H3,(H,17,18)
Raxofelast (IRFI 016) is a hydrophilic vitamin E-like antioxidant, that was developed to maximize the antioxidant potency of phenols related to vitamin E. It has been investigated as a mucoactive drug, a type of drug that is used for treatment of respiratory diseases. Also, in diabetic mice, raxofelast was shown to improve wound healing to a level close to that seen in healthy mice, and in another study it improved clinical outcomes in experimental burn wounds. In a rat model of myocardial damage, raxofelast was found to be a useful drug to reduce heart attacks. This compound has good bioavailability and physicochemical properties. No clinical trials have been conducted.
Originator
Approval Year
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NCI_THESAURUS |
C257
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100000080801
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128232-14-4
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6968
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DTXSID80926097
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C071049
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CHEMBL2105376
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SUB10263MIG
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65961
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TC0T0O9VYO
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C74328
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ACTIVE MOIETY