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Details

Stereochemistry RACEMIC
Molecular Formula C15H18O5
Molecular Weight 278.3004
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RAXOFELAST

SMILES

CC(=O)OC1=C(C)C2=C(OC(CC(O)=O)C2)C(C)=C1C

InChI

InChIKey=QLWBKUUORSULMI-UHFFFAOYSA-N
InChI=1S/C15H18O5/c1-7-8(2)15-12(5-11(20-15)6-13(17)18)9(3)14(7)19-10(4)16/h11H,5-6H2,1-4H3,(H,17,18)

HIDE SMILES / InChI
Raxofelast (IRFI 016) is a hydrophilic vitamin E-like antioxidant, that was developed to maximize the antioxidant potency of phenols related to vitamin E. It has been investigated as a mucoactive drug, a type of drug that is used for treatment of respiratory diseases. Also, in diabetic mice, raxofelast was shown to improve wound healing to a level close to that seen in healthy mice, and in another study it improved clinical outcomes in experimental burn wounds. In a rat model of myocardial damage, raxofelast was found to be a useful drug to reduce heart attacks. This compound has good bioavailability and physicochemical properties. No clinical trials have been conducted.

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Raxofelast, (+/-)5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic acid: a new antioxidant to modulate the inflammatory response during ischemia-reperfusion injury and impaired wound healing.
2007 Mar
Patents
Name Type Language
RAXOFELAST
INN  
INN  
Official Name English
raxofelast [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
Code System Code Type Description
SMS_ID
100000080801
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
PRIMARY
CAS
128232-14-4
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
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INN
6968
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
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EPA CompTox
DTXSID80926097
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
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MESH
C071049
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
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ChEMBL
CHEMBL2105376
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
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EVMPD
SUB10263MIG
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
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PUBCHEM
65961
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
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FDA UNII
TC0T0O9VYO
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
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NCI_THESAURUS
C74328
Created by admin on Sat Dec 16 17:49:56 GMT 2023 , Edited by admin on Sat Dec 16 17:49:56 GMT 2023
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