U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C46H71N11O11S
Molecular Weight 986.188
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NACARTOCIN

SMILES

[H][C@@]1(CCC(N)=O)NC(=O)[C@@]([H])(NC(=O)[C@H](CC2=CC=C(CC)C=C2)NC(=O)CCSCC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)[C@@H](C)CC

InChI

InChIKey=JPYLEKXLHLKVBI-IHJZLXGESA-N
InChI=1S/C46H71N11O11S/c1-6-26(5)39-45(67)52-29(14-15-35(47)58)41(63)54-33(23-36(48)59)42(64)53-30(16-19-69-20-17-38(61)51-32(43(65)56-39)22-28-12-10-27(7-2)11-13-28)46(68)57-18-8-9-34(57)44(66)55-31(21-25(3)4)40(62)50-24-37(49)60/h10-13,25-26,29-34,39H,6-9,14-24H2,1-5H3,(H2,47,58)(H2,48,59)(H2,49,60)(H,50,62)(H,51,61)(H,52,67)(H,53,64)(H,54,63)(H,55,66)(H,56,65)/t26-,29-,30-,31-,32-,33-,34-,39-/m0/s1

HIDE SMILES / InChI
Nacartocin is synthetic oxytocin analogue patented by Ceskoslovenska Akademie as a specific natriuretic agent. The natriuretic effect is mainly due to the inhibitory action of the peptide on tubular sodium resorption. Nacartocin decreased the blood pressure of anesthetized rats by the decrease of the total peripheral resistance which was greater than that observed after oxytocin administration.

Approval Year

PubMed

PubMed

TitleDatePubMed
Natriuretic properties of [2-p-ethylphenylalanine] deamino-6-carba-oxytocin (Nacartocin) in cats.
1984 Oct
Patents

Patents

Name Type Language
NACARTOCIN
INN  
INN  
Official Name English
1-(3-MERCAPTOPROPIONIC ACID)-2-(3-(P-ETHYLPHENYL)-L-ALANINE)-6-(L-2-AMINOBUTYRIC ACID)OXYTOCIN
Common Name English
nacartocin [INN]
Common Name English
GLYCINAMIDE, N-(3-MERCAPTO-1-OXOPROPYL)-L-TYROSYL-L-ISOLEUCYL-L-GLUTAMINYL-L-ASPARAGINYL-L-CYSTEINYL-L-PROLYL-L-LEUCYL-, CYCLIC (1->5)-DISULFIDE
Common Name English
Code System Code Type Description
INN
5347
Created by admin on Fri Dec 15 16:05:51 GMT 2023 , Edited by admin on Fri Dec 15 16:05:51 GMT 2023
PRIMARY
PUBCHEM
6917772
Created by admin on Fri Dec 15 16:05:51 GMT 2023 , Edited by admin on Fri Dec 15 16:05:51 GMT 2023
PRIMARY
SMS_ID
100000084407
Created by admin on Fri Dec 15 16:05:51 GMT 2023 , Edited by admin on Fri Dec 15 16:05:51 GMT 2023
PRIMARY
EVMPD
SUB09108MIG
Created by admin on Fri Dec 15 16:05:51 GMT 2023 , Edited by admin on Fri Dec 15 16:05:51 GMT 2023
PRIMARY
NCI_THESAURUS
C170194
Created by admin on Fri Dec 15 16:05:51 GMT 2023 , Edited by admin on Fri Dec 15 16:05:51 GMT 2023
PRIMARY
EPA CompTox
DTXSID801024617
Created by admin on Fri Dec 15 16:05:51 GMT 2023 , Edited by admin on Fri Dec 15 16:05:51 GMT 2023
PRIMARY
CAS
77727-10-7
Created by admin on Fri Dec 15 16:05:51 GMT 2023 , Edited by admin on Fri Dec 15 16:05:51 GMT 2023
PRIMARY
ChEMBL
CHEMBL2218901
Created by admin on Fri Dec 15 16:05:51 GMT 2023 , Edited by admin on Fri Dec 15 16:05:51 GMT 2023
PRIMARY
FDA UNII
TA88W10B8Z
Created by admin on Fri Dec 15 16:05:51 GMT 2023 , Edited by admin on Fri Dec 15 16:05:51 GMT 2023
PRIMARY