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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H14N8O5S4
Molecular Weight 514.582
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of CEFMATILEN

SMILES

[H][C@]12SCC(SCSC3=CNN=N3)=C(N1C(=O)[C@H]2NC(=O)C(=N/O)\C4=CSC(N)=N4)C(O)=O

InChI

InChIKey=UEQVTKSAEXANEZ-YCRCPZNHSA-N
InChI=1S/C15H14N8O5S4/c16-15-18-5(2-30-15)8(21-28)11(24)19-9-12(25)23-10(14(26)27)6(3-29-13(9)23)31-4-32-7-1-17-22-20-7/h1-2,9,13,28H,3-4H2,(H2,16,18)(H,19,24)(H,26,27)(H,17,20,22)/b21-8-/t9-,13-/m1/s1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including http://google.com/patents/EP0467647B1 | https://www.ncbi.nlm.nih.gov/pubmed/11400306 | https://www.ncbi.nlm.nih.gov/pubmed/8585742 | https://www.ncbi.nlm.nih.gov/pubmed/9612604

Cefmatilen (codenamed S-1090) is an orally-active cephalosporin antibiotic, that shows high activity against a variety of Gram-positive and Gram-negative bacteria, including Streptococcus pyogenes and Neisseria gonorrhoeae.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (5)--Six-month repeated oral dose toxicity study and supplement study in rats].
2001 May
Patents

Patents

Sample Use Guides

200 mg 2 x/day for 8 days
Route of Administration: Oral
In Vitro Use Guide
The bactericidal activities of S-1090 and the other agents at four times the MIC for Escherichia coli ATCC 25922 were determined. An overnight culture in Mueller-Hinton broth was inoculated into fresh broth, and the mixture was incubated, with constant shaking, until the viability reached 2 3 10^6 to 3 3 10^6 CFU/ml. After the addition of antibiotics, the cultures were incubated at 358C and the number of viable cells was determined.
Name Type Language
CEFMATILEN
INN  
INN  
Official Name English
cefmatilen [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C357
Created by admin on Fri Dec 15 16:28:57 GMT 2023 , Edited by admin on Fri Dec 15 16:28:57 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID50161236
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SMS_ID
300000037037
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FDA UNII
T750UM24H8
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CAS
140128-74-1
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MESH
C419864
Created by admin on Fri Dec 15 16:28:57 GMT 2023 , Edited by admin on Fri Dec 15 16:28:57 GMT 2023
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WIKIPEDIA
CEFMATILEN
Created by admin on Fri Dec 15 16:28:57 GMT 2023 , Edited by admin on Fri Dec 15 16:28:57 GMT 2023
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PUBCHEM
6400678
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ChEMBL
CHEMBL2104438
Created by admin on Fri Dec 15 16:28:57 GMT 2023 , Edited by admin on Fri Dec 15 16:28:57 GMT 2023
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NCI_THESAURUS
C76168
Created by admin on Fri Dec 15 16:28:57 GMT 2023 , Edited by admin on Fri Dec 15 16:28:57 GMT 2023
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INN
7839
Created by admin on Fri Dec 15 16:28:57 GMT 2023 , Edited by admin on Fri Dec 15 16:28:57 GMT 2023
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