Details
Stereochemistry | RACEMIC |
Molecular Formula | C15H23NO.ClH |
Molecular Weight | 269.81 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCC1(CCCCN(C)C1)C2=CC(O)=CC=C2
InChI
InChIKey=MPJUSISYVXABBH-UHFFFAOYSA-N
InChI=1S/C15H23NO.ClH/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13;/h6-8,11,17H,3-5,9-10,12H2,1-2H3;1H
DescriptionCurator's Comment: description was created based on several sources, including:
http://www.shijiebiaopin.net/upload/product/201222217302623.PDF | https://www.drugs.com/uk/meptid-tablets-200mg-leaflet.html
Curator's Comment: description was created based on several sources, including:
http://www.shijiebiaopin.net/upload/product/201222217302623.PDF | https://www.drugs.com/uk/meptid-tablets-200mg-leaflet.html
Meptazinol is a unique opioid analgesic. Binding studies suggest a relative selectivity for mu-1 opioid receptor sites. Meptid is indicated for the treatment of moderate to severe pain, including post-operative pain, obstetric pain and the pain of renal colic. The most commonly reported adverse reactions after treatment with meptazinol are nausea, vomiting, dizziness, diarrhoea and increased sweating, constipation, abdominal pain, rash, vertigo, headache, drowsiness, somnolence and dyspepsia.
CNS Activity
Originator
Sources: https://encrypted.google.com/patents/DE1941534A1
Curator's Comment: # Wyeth John & Brother Ltd.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P81908 Gene ID: NA Gene Symbol: BCHE Target Organism: Equus caballus (Horse) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3607358 |
3.6 µM [IC50] | ||
Target ID: CHEMBL3198 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3607358 |
0.4 µM [IC50] | ||
8.0 nM [Kd] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Meptid Approved UseThe drug is indicated for the treatment of moderate to severe pain, including post-operative pain, obstetric pain and the pain of renal colic. |
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Primary | Meptid Approved UseThe drug is indicated for the treatment of moderate to severe pain, including post-operative pain, obstetric pain and the pain of renal colic. |
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Primary | Meptid Approved UseThe drug is indicated for the treatment of moderate to severe pain, including post-operative pain, obstetric pain and the pain of renal colic. |
PubMed
Title | Date | PubMed |
---|---|---|
Enhancement of systemic and CNS delivery of meptazinol hydrochloride by intranasal administration to rats. | 2005 Aug |
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Pharmacokinetic behavior in plasma, cerebrospinal fluid and cerebral cortex after intranasal administration of hydrochloride meptazinol. | 2005 Sep 30 |
|
[Patient-controlled intravenous analgesia with remifentanil as an alternative to epidural analgesia during labor: case series and discussion of medicolegal aspects]. | 2010 Aug |
Patents
Sample Use Guides
Oral: One tablet (200 mg), with a glass of water, every four hours.
Intramuscular: 75-100mg. The injection may be repeated 2-4 hourly as required. For obstetric pain a dose of 100-150mg should be used according to weight. This dose should approximate 2mg/kg.
Intravenous: 50-100mg by slow intravenous injection. The injection may be repeated 2-4 hourly as required. If vomiting occurs, a suitable antiemetic should be given.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6141283
Approximately 20 to 40% of 3H-opiate binding is inhibited by meptazinol at concentrations less than 5 nM, whereas the inhibition for D-[3H]Ala2-D-Leu5-enkaphalin usually ranges from 15 to 20%.
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C67413
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100000086403
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59263-76-2
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11347
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65483
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C87361
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SUB03161MIG
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m7200
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261-683-0
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DTXSID3045485
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CHEMBL314437
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ACTIVE MOIETY
SUBSTANCE RECORD