Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C29H36O4 |
| Molecular Weight | 448.5937 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1(OC(C)(O2)C6=CC=CC=C6)C(C)=O
InChI
InChIKey=AHBKIEXBQNRDNL-BXXPAUNWSA-N
InChI=1S/C29H36O4/c1-18(30)29-25(32-28(4,33-29)19-8-6-5-7-9-19)17-24-22-11-10-20-16-21(31)12-14-26(20,2)23(22)13-15-27(24,29)3/h5-9,16,22-25H,10-15,17H2,1-4H3/t22-,23+,24+,25-,26+,27+,28?,29-/m1/s1
Dihydroxyprogesterone acetophenide (DHPA; brand name Topasel), also known as algestone acetophenide, is a steroidal progestin that is used as a contraceptive in combination with estradiol enanthate. Unlike many other 17α-hydroxyprogesterone derivatives, dihydroxyprogesterone acetophenide was reported to possess no glucocorticoid activity.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Vaginal bleeding patterns in users of Perlutal, a once-a-month injectable contraceptive consisting of 10 mg estradiol enanthate combined with 150 mg dihydroxyprogesterone acetophenide. A trial of 5462 woman-months. | 1998 Jul |
|
| Efficacy, acceptability, and clinical effects of a low-dose injectable contraceptive combination of dihydroxyprogesterone acetophenide and estradiol enanthate. | 2000 Apr |
|
| Comparison of two regimens of a monthly injectable contraceptive containing dihydroxyprogesterone acetophenide and estradiol enanthate. | 2006 Mar |
Patents
Sample Use Guides
Intramuscular ampule, preferably in the gluteal region, eight days after the onset of menstruation. If it is impossible to apply the medication in the 8th. day of the cycle, the same results are obtained administering it between the 7th. and 10th. days. In the following cycles a light bulb will be applied eight days after the start of menstruation.
Route of Administration:
Intramuscular
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T379IG5RV1
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68280
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214-649-4
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102011
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DTXSID40101706
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1179-87-9
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67831
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SUBSTANCE RECORD
