Details
Stereochemistry | RACEMIC |
Molecular Formula | C18H29NO4.ClH |
Molecular Weight | 359.888 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)NCC(O)COC1=CC=C(OCCOCC2CC2)C=C1
InChI
InChIKey=IFQJSQQPCCLGLZ-UHFFFAOYSA-N
InChI=1S/C18H29NO4.ClH/c1-14(2)19-11-16(20)13-23-18-7-5-17(6-8-18)22-10-9-21-12-15-3-4-15;/h5-8,14-16,19-20H,3-4,9-13H2,1-2H3;1H
Cicloprolol is a beta-adrenoceptor antagonist patented by French pharmaceutical company Synthelabo S. A. for treatment of heart disorders. Cicloprolol has a weak beta-agonistic effect at normal levels of adrenergic discharge and acts as an antagonist at high levels of discharge. In clinical trials, Cicloprolol did not affect resting heart rate and blood pressure, but it reduced significantly peak exercise heart rate and peak rate-pressure product. The effect was especially significant in patients with sinus rhythm. The drug did not induce bradycardia or arrhyth- mias. Resting and exercise ejection rate were not affected. Cicloprolol improved the quality of life and the work capacity of 40% of patients with congestive failure due to ischemic etiology. Side effects were few and similar to placebo and cicloprolol.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1347258
100 mg/day for 2 weeks
Route of Administration:
Oral
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C29576
Created by
admin on Fri Dec 15 17:42:04 GMT 2023 , Edited by admin on Fri Dec 15 17:42:04 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
DTXSID20979981
Created by
admin on Fri Dec 15 17:42:04 GMT 2023 , Edited by admin on Fri Dec 15 17:42:04 GMT 2023
|
PRIMARY | |||
|
C053708
Created by
admin on Fri Dec 15 17:42:04 GMT 2023 , Edited by admin on Fri Dec 15 17:42:04 GMT 2023
|
PRIMARY | |||
|
CHEMBL2110772
Created by
admin on Fri Dec 15 17:42:04 GMT 2023 , Edited by admin on Fri Dec 15 17:42:04 GMT 2023
|
PRIMARY | |||
|
167446
Created by
admin on Fri Dec 15 17:42:04 GMT 2023 , Edited by admin on Fri Dec 15 17:42:04 GMT 2023
|
PRIMARY | |||
|
C90795
Created by
admin on Fri Dec 15 17:42:04 GMT 2023 , Edited by admin on Fri Dec 15 17:42:04 GMT 2023
|
PRIMARY | |||
|
63686-79-3
Created by
admin on Fri Dec 15 17:42:04 GMT 2023 , Edited by admin on Fri Dec 15 17:42:04 GMT 2023
|
PRIMARY | |||
|
T355YD4791
Created by
admin on Fri Dec 15 17:42:04 GMT 2023 , Edited by admin on Fri Dec 15 17:42:04 GMT 2023
|
PRIMARY | |||
|
W-57
Created by
admin on Fri Dec 15 17:42:04 GMT 2023 , Edited by admin on Fri Dec 15 17:42:04 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD