Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C28H27FN6O2 |
| Molecular Weight | 498.5514 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C(C)=CC(=C1C(=O)C(=O)NC2=CC=C(C=C2)N3CCN(CC3)C4=NC=C(F)C=N4)C5=CC=CC=C5
InChI
InChIKey=SUFPWYYDCOKDLL-UHFFFAOYSA-N
InChI=1S/C28H27FN6O2/c1-19-16-24(20-6-4-3-5-7-20)25(33(19)2)26(36)27(37)32-22-8-10-23(11-9-22)34-12-14-35(15-13-34)28-30-17-21(29)18-31-28/h3-11,16-18H,12-15H2,1-2H3,(H,32,37)
F-901318 (Olorofim) is an orotomide antifungal drug. An investigation into the mechanism of action of F-901318 found that it acts via inhibition of the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH) in a fungal-specific manner. Olorofim is being developed by F2G for the treatment of mycoses.
Originator
Approval Year
Sample Use Guides
Phase II study: 30mg with a maximum daily dose of 300mg
Route of Administration:
Oral
The antifungal effects of F901318 against Aspergillus fumigatus were investigated. Live cell imaging revealed that, at a concentration of 0.1 μg/ml, F901318 completely inhibited germination, but conidia continued to expand by isotropic growth for >120 h. When this low F901318 concentration was applied to germlings or vegetative hyphae, their elongation was completely inhibited within 10 h.
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| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
721719
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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EU-Orphan Drug |
EU/3/16/1738
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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FDA ORPHAN DRUG |
829821
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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FDA ORPHAN DRUG |
704219
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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FDA ORPHAN DRUG |
814021
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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FDA ORPHAN DRUG |
702219
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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| Code System | Code | Type | Description | ||
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KL-204
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DB15245
Created by
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100000181846
Created by
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PRIMARY | |||
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10648
Created by
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EU/3/16/1713(POSITIVE)
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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PRIMARY | On 29 August 2016, orphan designation (EU/3/16/1713) was granted by the European Commission to F2G Ltd, United Kingdom, for 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(5-fluoro-pyrimidin-2-yl)piperazin-1-yl]-phenyl}-2-oxo-acetamide (also known as F901318) for the treatment of scedosporiosis. | ||
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EU/3/16/1738(POSITIVE)
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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PRIMARY | On 14 October 2016, orphan designation (EU/3/16/1738) was granted by the European Commission to F2G Ltd, United Kingdom, for 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(5-fluoro-pyrimidin-2-yl)piperazin-1-yl]-phenyl}-2-oxo-acetamide (also known as F901318) for the treatment of invasive aspergillosis. | ||
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91885568
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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C170250
Created by
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T34SH2H9HI
Created by
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1928707-56-5
Created by
admin on Sat Dec 16 11:49:00 GMT 2023 , Edited by admin on Sat Dec 16 11:49:00 GMT 2023
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PRIMARY |
ACTIVE MOIETY
