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Details

Stereochemistry ABSOLUTE
Molecular Formula C23H29NO5
Molecular Weight 399.4809
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 21-DESACETYLDEFLAZACORT

SMILES

CC1=N[C@]2(C(=O)CO)[C@@]([H])(C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4([H])[C@]([H])(C[C@@]32C)O)O1

InChI

InChIKey=KENSGCYKTRNIST-RVUAFKSESA-N
InChI=1S/C23H29NO5/c1-12-24-23(18(28)11-25)19(29-12)9-16-15-5-4-13-8-14(26)6-7-21(13,2)20(15)17(27)10-22(16,23)3/h6-8,15-17,19-20,25,27H,4-5,9-11H2,1-3H3/t15-,16-,17-,19+,20+,21-,22-,23+/m0/s1

HIDE SMILES / InChI

Description
Curator's Comment:: description was created based on several sources, including, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763756/

Deflazacort is a glucocorticoid developed for the treatment of different inflammatory and immune conditions. The drug is rapidly metabolized to an active metabolite, 21-hydroxy-deflazaxort that may cross the blood brain barrier. Deflazacort acts by suppressing inflammatory response.

CNS Activity

Sources: www.ncbi.nlm.nih.gov/pubmed/10229911
Curator's Comment:: Deflazacort active metabolite, 21-hydroxy-deflazacort crosses the blood-brain barrier in very low concentrations.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CALCORT

Approved Use

Treat inflammation including asthma, arthritis and allergies; treat problems with skin, kidney, heart, digestive system, eyes or blood, treat problems where body has growths (tumours), suppress the immune system in transplant operations.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
381 ng/mL
0.9 mg/kg single, oral
dose: 0.9 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
21-DESACETYLDEFLAZACORT plasma
Homo sapiens
population: UNHEALTHY
age: ADOLESCENT
sex: UNKNOWN
food status: UNKNOWN
206 ng/mL
0.9 mg/kg single, oral
dose: 0.9 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
21-DESACETYLDEFLAZACORT plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
655 ng × h/mL
0.9 mg/kg single, oral
dose: 0.9 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
21-DESACETYLDEFLAZACORT plasma
Homo sapiens
population: UNHEALTHY
age: ADOLESCENT
sex: UNKNOWN
food status: UNKNOWN
400 ng × h/mL
0.9 mg/kg single, oral
dose: 0.9 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
21-DESACETYLDEFLAZACORT plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
60%
0.9 mg/kg single, oral
dose: 0.9 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
21-DESACETYLDEFLAZACORT plasma
Homo sapiens
population: UNHEALTHY
age: ADOLESCENT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Other AEs: Cushingoid, Erythema...
Other AEs:
Cushingoid (69%)
Erythema (49%)
Hirsutism (37%)
Headache (34%)
Weight increased (32%)
Constipation (15%)
Abdominal pain upper (14%)
Skin striae (11%)
Acne (11%)
Abdominal discomfort (8%)
Sources: Page: 6.1
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Other AEs: Cushingoid, Weight increased...
Other AEs:
Cushingoid (33%)
Weight increased (20%)
Increased appetite (14%)
Upper respiratory tract infection (12%)
Cough (12%)
Pollakiuria (12%)
Nasopharyngitis (10%)
Hirsutism (10%)
Central obesity (10%)
Erythema (8%)
Irritability (8%)
Rhinorrhea (8%)
Abdominal discomfort (6%)
Sources: Page: Table 1
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Other AEs: Cushingoid, Hirsutism...
Other AEs:
Cushingoid (60%)
Hirsutism (35%)
Weight increased (28%)
Erythema (28%)
Central obesity (25%)
Abdominal pain (18%)
Pollakiuria (15%)
Constipation (10%)
Irritability (10%)
Abnormal behavior (9%)
Pyrexia (9%)
Back pain (7%)
Rash (7%)
Contusion (6%)
Nausea (6%)
Psychomotor hyperactivity (6%)
Epistaxis (6%)
Skin striae (6%)
Sources: Page: Table 1
AEs

AEs

AESignificanceDosePopulation
Acne 11%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Skin striae 11%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Abdominal pain upper 14%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Constipation 15%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Weight increased 32%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Headache 34%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Hirsutism 37%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Erythema 49%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Cushingoid 69%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Abdominal discomfort 8%
1.2 mg/kg 1 times / day multiple, oral
Higher than recommended
Dose: 1.2 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 1.2 mg/kg, 1 times / day
Sources: Page: 6.1
unhealthy, 5 - 15 years
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Sources: Page: 6.1
Central obesity 10%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Hirsutism 10%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Nasopharyngitis 10%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Cough 12%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Pollakiuria 12%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Upper respiratory tract infection 12%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Increased appetite 14%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Weight increased 20%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Cushingoid 33%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Abdominal discomfort 6%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Erythema 8%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Irritability 8%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Rhinorrhea 8%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Constipation 10%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Irritability 10%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Pollakiuria 15%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Abdominal pain 18%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Central obesity 25%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Erythema 28%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Weight increased 28%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Hirsutism 35%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Contusion 6%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Epistaxis 6%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Nausea 6%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Psychomotor hyperactivity 6%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Skin striae 6%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Cushingoid 60%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Back pain 7%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Rash 7%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Abnormal behavior 9%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
Pyrexia 9%
0.9 mg/kg 1 times / day multiple, oral
Recommended
Dose: 0.9 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.9 mg/kg, 1 times / day
Sources: Page: Table 1
unhealthy, 5 - 15 years
n = 51
Health Status: unhealthy
Condition: Duchenne muscular dystrophy
Age Group: 5 - 15 years
Sex: unknown
Population Size: 51
Sources: Page: Table 1
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
weak
weak
weak
weak
weak
weak
Drug as victimTox targets
PubMed

PubMed

TitleDatePubMed
Effectiveness of nifedipine and deflazacort in the management of distal ureter stones.
2000 Oct 1
Patents

Patents

Sample Use Guides

The usual dose for most conditions, including rheumatoid arthritis is half to three tablets each day, the dose for severe asthma may be up to 8 or 12 tablets each day.
Route of Administration: Oral
In Vitro Use Guide
Phytohaemagglutinin stimulated peripheral blood lymphocytes, NK and K cells were incubated with different concentrations of the drug (0, 1.2, 6.0, 24, 60, 240, and 600 x 10(-7) M) and the immunosuppressive effect was measured. Deflazacort suppressed the cells in a dose dependent way.
Name Type Language
21-DESACETYLDEFLAZACORT
Common Name English
L 6485
Code English
21-DESDFZ
Common Name English
5'.BETA.H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE, 11.BETA.,21-DIHYDROXY-2'-METHYL-
Systematic Name English
5'H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE, 11,21-DIHYDROXY-2'-METHYL-, (11.BETA.,16.BETA.)-
Systematic Name English
L-6485
Code English
DEFLAZACORT METABOLITE II
Common Name English
(11.BETA.,16.BETA.)-11,21-DIHYDROXY-2'-METHYL-5'H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE
Systematic Name English
DEACETYLDEFLAZACORT
Common Name English
Code System Code Type Description
PUBCHEM
3081431
Created by admin on Sat Jun 26 09:48:46 UTC 2021 , Edited by admin on Sat Jun 26 09:48:46 UTC 2021
PRIMARY
FDA UNII
T1LWN33J2P
Created by admin on Sat Jun 26 09:48:46 UTC 2021 , Edited by admin on Sat Jun 26 09:48:46 UTC 2021
PRIMARY
CAS
13649-57-5
Created by admin on Sat Jun 26 09:48:46 UTC 2021 , Edited by admin on Sat Jun 26 09:48:46 UTC 2021
PRIMARY