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Details

Stereochemistry ACHIRAL
Molecular Formula C16H10FN3
Molecular Weight 262.2716
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLORTAUCIPIR F-18

SMILES

[18F]C1=NC=C(C=C1)C2=CC3=C(C=C2)C4=C(N3)C=CN=C4

InChI

InChIKey=GETAAWDSFUCLBS-SJPDSGJFSA-N
InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H/i17-1

HIDE SMILES / InChI
Flortaucipir (18F-AV-1451, also known as 18F-T807) is a highly selective positron emission tomography (PET) imaging agent targeting paired helical filament (PHF)-tau in the brain. This tracer is studying for clinical assessment in patients with various tauopathies, including Alzheimer's disease, as well as in healthy subjects.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Quantification of Tau Load Using [(18)F]AV1451 PET.
2017 Dec
Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition.
2017 Mar 1
(18) F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study.
2017 Oct
(18)F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease.
2018 Feb
Patents

Patents

Sample Use Guides

Flortaucipir PET images were acquired for 20 min, as four 5-min frames, beginning 80 min after injection of 370 MBq flortaucipir. On a separate day, subjects underwent a florbetapir PET scan for 10 min, as two 5-min frames, beginning 50 min after injection of 370 MBq florbetapir F18.
Route of Administration: Parenteral
In Vitro Use Guide
Unknown
Name Type Language
FLORTAUCIPIR F-18
Common Name English
Flortaucipir (18F) [WHO-DD]
Common Name English
FLORTAUCIPIR F 18
USAN  
USAN  
Official Name English
LY3191748
Code English
7-(6-(F-18)FLUOROPYRIDIN-3-YL)-5H-PYRIDO(4,3-B)INDOLE
Common Name English
T807 F-18
Code English
FLORTAUCIPIR F 18 [USAN]
Common Name English
(F-18)T807
Code English
AV-1451 F-18
Code English
[18F]FLORTAUCIPIR
Common Name English
TAUVID
Brand Name English
18F-AV-1451
Code English
flortaucipir (¹⁸F) [INN]
Common Name English
T-807 F-18
Code English
FLORTAUCIPIR F18 [MI]
Common Name English
FLORTAUCIPIR F-18 [ORANGE BOOK]
Common Name English
FLORTAUCIPIR (18F)
INN   WHO-DD  
INN  
Official Name English
LY-3191748
Code English
Code System Code Type Description
PUBCHEM
70957463
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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DRUG BANK
DB14914
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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WIKIPEDIA
Flortaucipir (18F)
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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MERCK INDEX
m12220
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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USAN
CD-33
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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CAS
1522051-90-6
Created by admin on Sat Dec 16 09:53:51 GMT 2023 , Edited by admin on Sat Dec 16 09:53:51 GMT 2023
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EPA CompTox
DTXSID001027893
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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INN
10203
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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SMS_ID
100000178384
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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DAILYMED
T1JP1KYU9O
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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ChEMBL
CHEMBL3546271
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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FDA UNII
T1JP1KYU9O
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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RXCUI
2372689
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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NCI_THESAURUS
C171887
Created by admin on Sat Dec 16 09:53:52 GMT 2023 , Edited by admin on Sat Dec 16 09:53:52 GMT 2023
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