Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H10FN3 |
Molecular Weight | 262.2716 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[18F]C1=NC=C(C=C1)C2=CC3=C(C=C2)C4=C(N3)C=CN=C4
InChI
InChIKey=GETAAWDSFUCLBS-SJPDSGJFSA-N
InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H/i17-1
Flortaucipir (18F-AV-1451, also known as 18F-T807) is a highly selective positron emission tomography (PET) imaging agent targeting paired helical filament (PHF)-tau in the brain. This tracer is studying for clinical assessment in patients with various tauopathies, including Alzheimer's disease, as well as in healthy subjects.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Quantification of Tau Load Using [(18)F]AV1451 PET. | 2017 Dec |
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Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition. | 2017 Mar 1 |
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(18) F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study. | 2017 Oct |
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(18)F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease. | 2018 Feb |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28077397
Flortaucipir PET images were acquired for 20 min, as four 5-min frames, beginning 80 min after injection of 370 MBq flortaucipir. On a separate day, subjects underwent a florbetapir PET scan for 10 min, as two 5-min frames, beginning 50 min after injection of 370 MBq florbetapir F18.
Route of Administration:
Parenteral
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ACTIVE MOIETY