Details
Stereochemistry | ACHIRAL |
Molecular Formula | C17H17FN4S.ClH.H2O |
Molecular Weight | 382.883 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.Cl.CC1=CC2=C(N=C(N=C2S1)N3CCNCC3)C4=CC=CC=C4F
InChI
InChIKey=SAURKKOJWIFYSR-UHFFFAOYSA-N
InChI=1S/C17H17FN4S.ClH.H2O/c1-11-10-13-15(12-4-2-3-5-14(12)18)20-17(21-16(13)23-11)22-8-6-19-7-9-22;;/h2-5,10,19H,6-9H2,1H3;1H;1H2
DDP-225 (also known as MCI-225), a thienopyrimidine analog, is a selective noradrenaline reuptake inhibitor with serotonin receptor antagonism. It shows antidepressant-like properties in animal models. MCI-225 could be useful in the treatment of attentional deficits and related cognitive dysfunctions in psychiatric disorders.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11526964 | https://www.ncbi.nlm.nih.gov/pubmed/9450161
Curator's Comment: Known to be CNS active in rodents. Human data not available.
Originator
Approval Year
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9450161
MCI-225 inhibited the synaptosomal uptake of noradrenaline (Ki = 35.0 nM), serotonin (Ki = 491 nM), and dopamine (Ki = 14,800 nM, although it did not inhibit MAO-A and MAO-B activities. MCI-225 showed high affinity only for the 5-HT3 serotonin receptor (Ki = 81.0 nM).
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DB05642
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DTXSID40197221
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476148-82-0
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SZU399KT7Q
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ACTIVE MOIETY
SUBSTANCE RECORD