CLOPREDNOL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H25ClO5
Molecular Weight	392.873
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CLOPREDNOL

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C=C(Cl)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=YTJIBEDMAQUYSZ-FDNPDPBUSA-N

InChI=1S/C21H25ClO5/c1-19-5-3-11(24)7-14(19)15(22)8-12-13-4-6-21(27,17(26)10-23)20(13,2)9-16(25)18(12)19/h3,5,7-8,12-13,16,18,23,25,27H,4,6,9-10H2,1-2H3/t12-,13-,16-,18+,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6374803

Cloprednol is a steroid, which was used for the treatment of asthma. The exact mechanism of cloprednol action is unknown. The drug was marketed under several names, including Syntestan and Cloradryn, however, its current marketing status is unknown and supposed to be discontinued.

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Asthma 241 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6374803	Palliative		Approved 8429	SYNTESTAN Approved Use Asthma.

PubMed

PubMed

Title	Date	PubMed

Patents

Patents

Sample Use Guides

In Vivo Use Guide

Cloprednol is given as a single morning dose of 5-12.5 mg orally.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

CLOPREDNOL

Official Name

English

CLOPREDNOL [MI]

Common Name

English

6-Chloro-11β,17,21-trihydroxypregna-1,4,6-triene-3,20-dione

Systematic Name

English

RS-4691

Code

English

CLORADRYN

Brand Name

English

PREGNA-1,4,6-TRIENE-3,20-DIONE, 6-CHLORO-11,17,21-TRIHYDROXY-, (11.BETA.)-

Systematic Name

English

Cloprednol [WHO-DD]

Common Name

English

CLOPREDNOL [USAN]

Common Name

English

cloprednol [INN]

Common Name

English

CLOPREDNOL [MART.]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH02AB14

Created by admin on Sat Dec 16 18:01:57 GMT 2023 , Edited by admin on Sat Dec 16 18:01:57 GMT 2023

WHO-ATC

H02AB14

Created by admin on Sat Dec 16 18:01:57 GMT 2023 , Edited by admin on Sat Dec 16 18:01:57 GMT 2023

NCI_THESAURUS

C521

Created by admin on Sat Dec 16 18:01:57 GMT 2023 , Edited by admin on Sat Dec 16 18:01:57 GMT 2023

Code System Code Type Description

DRUG CENTRAL

709

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DRUG BANK

DB13843

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SMS_ID

100000084000

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ChEMBL

CHEMBL1697832

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RXCUI

21285

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RxNorm

FDA UNII

SYP56O3GJG

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CAS

5251-34-3

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MERCK INDEX

m3657

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Merck Index

INN

3566

Created by admin on Sat Dec 16 18:01:57 GMT 2023 , Edited by admin on Sat Dec 16 18:01:57 GMT 2023

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WIKIPEDIA

Cloprednol

Created by admin on Sat Dec 16 18:01:57 GMT 2023 , Edited by admin on Sat Dec 16 18:01:57 GMT 2023

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MESH

C011731

Created by admin on Sat Dec 16 18:01:57 GMT 2023 , Edited by admin on Sat Dec 16 18:01:57 GMT 2023

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PUBCHEM

5284535

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ECHA (EC/EINECS)

226-052-6

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NCI_THESAURUS

C80809

Created by admin on Sat Dec 16 18:01:57 GMT 2023 , Edited by admin on Sat Dec 16 18:01:57 GMT 2023

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EVMPD

SUB06744MIG

Created by admin on Sat Dec 16 18:01:57 GMT 2023 , Edited by admin on Sat Dec 16 18:01:57 GMT 2023

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EPA CompTox

DTXSID1022849

Created by admin on Sat Dec 16 18:01:57 GMT 2023 , Edited by admin on Sat Dec 16 18:01:57 GMT 2023

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ACTIVE MOIETY


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