FITUSIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Name

Type

Language

FITUSIRAN

Official Name

English

ALN-AT3SC

Code

English

RNA, ((2'-DEOXY-2'-FLUORO)G-SP-GM-SP-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)C-AM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-CM-(2'-DEOXY-2'-FLUORO)U-U

Systematic Name

English

SMALL INTERFERING RNA (SIRNA) INHIBITING ANTITHROMBIN LIVER PRODUCTION: DUPLEX OF ((2S,4R)-1-(1-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-16,16-BIS((3-((3-(5-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)PENTANAMIDO)PROPYL)AMINO)-3-OXOPR

Systematic Name

English

Fitusiran [WHO-DD]

Common Name

English

ALN-57213

Code

English

FITUSIRAN [USAN]

Common Name

English

fitusiran [INN]

Common Name

English

Code System Code Type Description

INN

10177

Created by admin on Sat Dec 16 11:09:36 UTC 2023 , Edited by admin on Sat Dec 16 11:09:36 UTC 2023

PRIMARY

NCI_THESAURUS

C169984

Created by admin on Sat Dec 16 11:09:36 UTC 2023 , Edited by admin on Sat Dec 16 11:09:36 UTC 2023

PRIMARY

DRUG BANK

DB15002

Created by admin on Sat Dec 16 11:09:36 UTC 2023 , Edited by admin on Sat Dec 16 11:09:36 UTC 2023

PRIMARY

CAS

1499251-18-1

Created by admin on Sat Dec 16 11:09:36 UTC 2023 , Edited by admin on Sat Dec 16 11:09:36 UTC 2023

PRIMARY

USAN

FG-138

Created by admin on Sat Dec 16 11:09:36 UTC 2023 , Edited by admin on Sat Dec 16 11:09:36 UTC 2023

PRIMARY

FDA UNII

SV9W47ZLE1

Created by admin on Sat Dec 16 11:09:36 UTC 2023 , Edited by admin on Sat Dec 16 11:09:36 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_2;1_4;1_6;1_8;1_10;1_14;1_16;1_18;1_20;2_1;2_3;2_5;2_7;2_9-2_11;2_13;2_15;2_17;2_19;2_21-2_22	22 / 45
2'-O-Methyl-Ribose	1_1;1_3;1_5;1_7;1_9;1_11-1_13;1_15;1_17;1_19;1_21-1_23;2_2;2_4;2_6;2_8;2_12;2_14;2_16;2_18;2_20	23 / 45

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_3;1_22-1_23;2_2-2_3	6 / 43
Phosphate	1_4-1_21;2_4-2_22	37 / 43

ACTIVE MOIETY


					SV9W47ZLE1

FITUSIRAN

SALT/SOLVATE (PARENT)


					A2PQ8BS44A

FITUSIRAN SODIUM